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dc.creatorKerber, R.-
dc.creatorReindl, S.-
dc.creatorRomanowski, Victor-
dc.creatorGomez, Ricardo Martin-
dc.creatorOgbaini Emovon, E.-
dc.creatorGünther, S.-
dc.creatorter Meulen, J.-
dc.date2018-06-08T19:28:50Z-
dc.date2018-06-08T19:28:50Z-
dc.date2015-03-
dc.date2018-06-08T14:28:36Z-
dc.date.accessioned2019-04-29T15:51:56Z-
dc.date.available2019-04-29T15:51:56Z-
dc.date.issued2015-03-
dc.identifierKerber, R.; Reindl, S.; Romanowski, Victor; Gomez, Ricardo Martin; Ogbaini Emovon, E.; et al.; Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps; Elsevier Science; Journal of Clinical Virology; 64; 3-2015; 120-127-
dc.identifier1386-6532-
dc.identifierhttp://hdl.handle.net/11336/47954-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/304059-
dc.descriptionSignificant progress has been made in the past 10 years in unraveling the molecular biology of highly pathogenic arenaviruses that are endemic in several West African countries (Lassa fever virus) and in some regions of South America (Argentine and Bolivian hemorrhagic fever viruses). While this has resulted in proof-of-concept studies of novel vaccine candidates in non-human primates and in the discovery of several novel antiviral small molecule drug candidates, none of them has been tested in the clinic to date. The recent Ebola outbreak in West Africa has demonstrated very clearly that there is an urgent need to develop the prophylactic and therapeutic armamentarium against viral hemorrhagic fever viruses as part of a global preparedness for future epidemics. As it pertains to this goal, the present article summarizes the current knowledge of highly pathogenic arenaviruses and identifies opportunities for translational research.-
dc.descriptionFil: Kerber, R.. Bernhard Nocht Institute for Tropical Medicine; Alemania-
dc.descriptionFil: Reindl, S.. Bernhard Nocht Institute for Tropical Medicine; Alemania-
dc.descriptionFil: Romanowski, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina-
dc.descriptionFil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina-
dc.descriptionFil: Ogbaini Emovon, E.. Irrua Specialist Teaching Hospital; Nigeria-
dc.descriptionFil: Günther, S.. Bernhard Nocht Institute for Tropical Medicine; Alemania-
dc.descriptionFil: ter Meulen, J.. Philipps University Marburg; Alemania-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherElsevier Science-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.jcv.2014.12.004-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1386653214004661-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectArenavirus-
dc.subjectviral hemorrhagic fever-
dc.subjectLassa virus-
dc.subjectJunin virus-
dc.subjectvaccine-
dc.subjectantiviral-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleResearch efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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