Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Loscalzo, Leonardo Martin | - |
| dc.creator | Yow, Tin T. | - |
| dc.creator | Wasowski, Cristina Lucia N. | - |
| dc.creator | Chebib, Mary | - |
| dc.creator | Marder, Nora Mariel | - |
| dc.date | 2017-06-14T18:51:16Z | - |
| dc.date | 2017-06-14T18:51:16Z | - |
| dc.date | 2011-09 | - |
| dc.date | 2017-06-14T14:34:26Z | - |
| dc.date.accessioned | 2019-04-29T15:51:59Z | - |
| dc.date.available | 2019-04-29T15:51:59Z | - |
| dc.date.issued | 2011-09 | - |
| dc.identifier | Loscalzo, Leonardo Martin; Yow, Tin T.; Wasowski, Cristina Lucia N.; Chebib, Mary; Marder, Nora Mariel; Hesperidin induces antinociceptive effect in mice and its aglicone, hesperetin, binds to mu-opioid; Elsevier Inc; Pharmacology Biochemistry And Behavior; 99; 3; 9-2011; 333-341 | - |
| dc.identifier | 0091-3057 | - |
| dc.identifier | http://hdl.handle.net/11336/18187 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/304077 | - |
| dc.description | This paper extended the evaluation of the depressant and antinociceptive activities of hesperidin in order to determine its effectiveness by the intraperitoneal and oral routes, its pharmacological interaction with diverse pathways of neurotransmission and the role of its aglycone, hesperetin. The capacity of hesperidin and hesperetin to bind to μ-opioid receptor and their actions on μ-opioid receptor co-expressed with GIRK1/GIRK2 channels (G protein-activated inwardly rectifying K+ channels) in Xenopus laevis oocytes were also determined. Hesperidin exhibited a depressant activity in the hole board and locomotor activity tests, antinociceptive activities in the abdominal writhing and hot plate tests and no motor incoordination in the inverted screen and rotarod assays, only by the intraperitoneal route. Hesperetin did not show any effects in vivo in mice in these models, but in vitro it displaced the [3H]DAMGO binding with low-affinity and inhibited inward currents through the expressed GIRK1/2 channels. Although hesperidin actions in vivo demonstrated to be mediated by an opioid mechanism of action, it failed to directly bind to and activate the μ-opioid receptor or produce any change on inward GIRK1/2 currents in vitro. However, it should be considered that hesperidin may be metabolized, possibly resulting in crucial changes in its biological activity. | - |
| dc.description | Fil: Loscalzo, Leonardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. University of Sidney; Australia | - |
| dc.description | Fil: Yow, Tin T.. University of Sidney; Australia | - |
| dc.description | Fil: Wasowski, Cristina Lucia N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina | - |
| dc.description | Fil: Chebib, Mary. University of Sidney; Australia | - |
| dc.description | Fil: Marder, Nora Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0091305711001602 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pbb.2011.05.018 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Hesperidin | - |
| dc.subject | Hesperetin | - |
| dc.subject | Depressant | - |
| dc.subject | Antinociception | - |
| dc.subject | mu-opioid receptor | - |
| dc.subject | Xenopus oocytes | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Hesperidin induces antinociceptive effect in mice and its aglicone, hesperetin, binds to mu-opioid | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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