Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Silva, Izabella T. | - |
| dc.creator | Geller, Fabiana Cristina | - |
| dc.creator | Persich, Lara | - |
| dc.creator | Dudek, Sabine E. | - |
| dc.creator | Lang, Karen L. | - |
| dc.creator | Caro, Miguel S. B. | - |
| dc.creator | Duran, Fernando Javier | - |
| dc.creator | Schenkel, Eloir P. | - |
| dc.creator | Ludwig, Stephan | - |
| dc.creator | Simoes, Cláudia M. O. | - |
| dc.date | 2017-06-22T21:29:33Z | - |
| dc.date | 2017-06-22T21:29:33Z | - |
| dc.date | 2016-04 | - |
| dc.date | 2017-06-22T17:38:30Z | - |
| dc.date.accessioned | 2019-04-29T15:52:00Z | - |
| dc.date.available | 2019-04-29T15:52:00Z | - |
| dc.date.issued | 2016-04 | - |
| dc.identifier | Silva, Izabella T.; Geller, Fabiana Cristina; Persich, Lara; Dudek, Sabine E.; Lang, Karen L.; et al.; Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549; Springer; Investigational New Drugs; 34; 2; 4-2016; 139-148 | - |
| dc.identifier | 0167-6997 | - |
| dc.identifier | http://hdl.handle.net/11336/18721 | - |
| dc.identifier | 1573-0646 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/304087 | - |
| dc.description | Cucurbitacins and their derivatives are triterpenoids that are found in various plant families, and are known for their pharmacological and biological activities, including anti-cancer effects. Lung cancer represents a major public health problem, with non-small-cell lung cancer (NSCLC) being the most frequent and aggressive type of lung cancer. The objective of this work was to evaluate four cucurbitacins (CUCs) for their cytotoxic activity, effects on apoptosis induction, cell cycle progression, anti-migratory, and anti-invasive effects on the human NSCLC cell line (A549 cells). Our findings showed that these CUCs could suppress human NSCLC cell growth in vitro through their effects on the PI3Kinase and MAPK pathways, which lead to programmed cell death induction, as well as inhibition of cell migration and cell invasion. Additionally, these effects culminate in apoptosis induction and G2/M cell cycle arrest by modulating cyclin B1 expression, and in the mitigation of strategic steps of lung cancer metastasis, including migration and invasion of A549 cells. These results suggest that two natural (DDCB and CB) and two novel semisynthetic derivatives of cucurbitacin B (ACB and DBCB) could be considered as promising compounds with antitumor potential. | - |
| dc.description | Fil: Silva, Izabella T.. Universidade Federal Da Santa Catarina; Brasil | - |
| dc.description | Fil: Geller, Fabiana Cristina. Universidade Federal Da Santa Catarina; Brasil | - |
| dc.description | Fil: Persich, Lara. Universidade Federal Da Santa Catarina; Brasil | - |
| dc.description | Fil: Dudek, Sabine E.. Westfalische Wilhelms Universitat; Alemania | - |
| dc.description | Fil: Lang, Karen L.. Universidade Federal Da Santa Catarina; Brasil | - |
| dc.description | Fil: Caro, Miguel S. B.. Universidade Federal Da Santa Catarina; Brasil | - |
| dc.description | Fil: Duran, Fernando Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina | - |
| dc.description | Fil: Schenkel, Eloir P.. Universidade Federal Da Santa Catarina; Brasil | - |
| dc.description | Fil: Ludwig, Stephan. Westfalische Wilhelms Universitat; Alemania | - |
| dc.description | Fil: Simoes, Cláudia M. O.. Universidade Federal Da Santa Catarina; Brasil | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Springer | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10637-015-0317-4 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10637-015-0317-4 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | CUCURBITACINAS | - |
| dc.subject | APOPTOSIS | - |
| dc.subject | INVASION | - |
| dc.subject | METASTASIS | - |
| dc.subject | Otras Ciencias Químicas | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549 | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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