Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Caballero, Marina | - |
| dc.creator | Alonso, Andrés Mariano | - |
| dc.creator | Deng, Bin | - |
| dc.creator | Attias, Marcia | - |
| dc.creator | De Souza, Wanderley | - |
| dc.creator | Corvi, Maria Martha | - |
| dc.date | 2018-07-31T18:22:48Z | - |
| dc.date | 2018-07-31T18:22:48Z | - |
| dc.date | 2016-04 | - |
| dc.date | 2018-07-31T17:22:26Z | - |
| dc.date.accessioned | 2019-04-29T15:52:12Z | - |
| dc.date.available | 2019-04-29T15:52:12Z | - |
| dc.date.issued | 2016-04 | - |
| dc.identifier | Caballero, Marina; Alonso, Andrés Mariano; Deng, Bin; Attias, Marcia; De Souza, Wanderley; et al.; Identification of new palmitoylated proteins in Toxoplasma gondii; Elsevier Science; Biochimica Et Biophysica Acta-proteins And Proteomics; 1864; 4; 4-2016; 400-408 | - |
| dc.identifier | 1570-9639 | - |
| dc.identifier | http://hdl.handle.net/11336/53623 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/304186 | - |
| dc.description | Protein palmitoylation has been shown to be an important post-translational modification in eukaryotic cells. This modification alters the localization and/or the function of the targeted protein. In recent years, protein palmitoylation has risen in importance in apicomplexan parasites as well. In Toxoplasma gondii, some proteins have been reported to be modified by palmitate. With the development of new techniques that allow the isolation of palmitoylated proteins, this significant post-translational modification has begun to be studied in more detail in T. gondii. Here we describe the palmitoylome of the tachyzoite stage of T. gondii using a combination of the acyl-biotin exchange chemistry method and mass spectrometry analysis. We identified 401 proteins found in multiple cellular compartments, with a wide range of functions that vary from metabolic processes, gliding and host-cell invasion to even regulation of transcription and translation. Besides, we found that more rhoptry proteins than the ones already described for Toxoplasma are palmitoylated, suggesting an important role for this modification in the invasion mechanism of the host-cell. This study documents that protein palmitoylation is a common modification in T. gondii that could have an impact on different cellular processes. | - |
| dc.description | Fil: Caballero, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; Argentina | - |
| dc.description | Fil: Alonso, Andrés Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; Argentina | - |
| dc.description | Fil: Deng, Bin. University of Vermont; Estados Unidos | - |
| dc.description | Fil: Attias, Marcia. Universidade Federal do Rio de Janeiro; Brasil | - |
| dc.description | Fil: De Souza, Wanderley. Universidade Federal do Rio de Janeiro; Brasil | - |
| dc.description | Fil: Corvi, Maria Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Science | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbapap.2016.01.010 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1570963916300024 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ACYL-BIOTIN EXCHANGE | - |
| dc.subject | HOST-CELL INVASION | - |
| dc.subject | PALMITOYLOME | - |
| dc.subject | PROTEIN IDENTIFICATION | - |
| dc.subject | RHOPTRY | - |
| dc.subject | TOXOPLASMA GONDII | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Identification of new palmitoylated proteins in Toxoplasma gondii | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.