Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Spitzmaul, Guillermo Federico | - |
| dc.creator | Tolosa, Leonardo | - |
| dc.creator | Winkelman, Beerend H. J. | - |
| dc.creator | Heidenreich, Matthias | - |
| dc.creator | Frens, Maartens | - |
| dc.creator | Chabbert, Christian | - |
| dc.creator | de Zeeuw, Chris I. | - |
| dc.creator | Jentsch, Thomas J. | - |
| dc.date | 2016-03-01T15:58:33Z | - |
| dc.date | 2016-03-01T15:58:33Z | - |
| dc.date | 2013-03 | - |
| dc.date | 2016-03-30 10:35:44.97925-03 | - |
| dc.date.accessioned | 2019-04-29T15:52:15Z | - |
| dc.date.available | 2019-04-29T15:52:15Z | - |
| dc.date.issued | 2013-03 | - |
| dc.identifier | Spitzmaul, Guillermo Federico; Tolosa, Leonardo; Winkelman, Beerend H. J.; Heidenreich, Matthias; Frens, Maartens; et al.; Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models; American Society For Biochemistry And Molecular Biology; Journal Of Biological Chemistry; 288; 13; 3-2013; 9334-9344 | - |
| dc.identifier | 0021-9258 | - |
| dc.identifier | http://hdl.handle.net/11336/4553 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/304212 | - |
| dc.description | The function of sensory hair cells of the cochlea and vestibular organs depends on an influx of K+ through apical mechanosensitive ion channels and its subsequent removal over their basolateral membrane. The KCNQ4 (Kv7.4) K+ channel, which is mutated in DFNA2 human hearing loss, is expressed in the basal membrane of cochlear outer hair cells (OHCs) where it may mediate K+ efflux. Like the related K+ channel KCNQ5 (Kv7.5), KCNQ4 is also found at calyx terminals ensheathing type I vestibular hair cells where it may be localized pre- or postsynaptically. Making use of Kcnq4-/- mice lacking KCNQ4, as well as Kcnq4dn/dn and Kcnq5dn/dn mice expressing dominant negative channel mutants, we now show unambiguously that in adult mice both channels reside in postsynaptic calyx-forming neurons, but cannot be detected in the innervated hair cells. Accordingly whole-cell currents of vestibular hair cells did not differ between genotypes. Neither Kcnq4-/-, Kcnq5dn/dn nor Kcnq4-/-/Kcnq5dn/dn double mutant mice displayed circling behavior found with severe vestibular impairment. However, a milder form of vestibular dysfunction was apparent from altered vestibulo-ocular reflexes in Kcnq4-/-/Kcnq5dn/dn and Kcnq4-/- mice. The larger impact of KCNQ4 may result from its preferential expression in central zones of maculae and cristae, which are innervated by phasic neurons that are more sensitive than the tonic neurons predominantly present in the surrounding peripheral zones where KCNQ5 is found. The impact of postsynaptic KCNQ4 on vestibular function may be related to K+ removal and modulation of synaptic transmission. | - |
| dc.description | Fil: Spitzmaul, Guillermo Federico. Leibniz Institut Fur Molekulare Pharmakologie; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina | - |
| dc.description | Fil: Tolosa, Leonardo. Netherlands Institute For Neuroscience; Países Bajos | - |
| dc.description | Fil: Winkelman, Beerend H. J.. Netherlands Institute For Neuroscience; Países Bajos | - |
| dc.description | Fil: Heidenreich, Matthias. Leibniz_Institut Fur Molekulare Pharmakologie (Fmp) ; Alemania | - |
| dc.description | Fil: Frens, Maartens. Department Of Neurosciences, Erasmus; Países Bajos | - |
| dc.description | Fil: Chabbert, Christian. Institut Des Neurosciences De Montpellier; Francia | - |
| dc.description | Fil: de Zeeuw, Chris I.. Netherlands Institute For Neuroscience; Países Bajos | - |
| dc.description | Fil: Jentsch, Thomas J.. Charité-Universitätsmedizin. Cluster of Excellence NeuroCure; Alemania | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society For Biochemistry And Molecular Biology | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611004/ | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1074/jbc.M112.433383 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/288/13/9334 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/issn/0021-9258 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | M CURRENTS | - |
| dc.subject | CALYX TERMINAL | - |
| dc.subject | UTRICLE | - |
| dc.subject | GENE DISRUPTION | - |
| dc.subject | Neurociencias | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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