1. RODNA
  2. CONICET
  3. CONICET
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.creatorEöry, M. L.-
dc.creatorZanuzzi, Carolina Natalia-
dc.creatorFuentealba, Nadia Analia-
dc.creatorSguazza, Guillermo Hernán-
dc.creatorGimeno, Eduardo Juan-
dc.creatorGalosi, Cecilia Monica-
dc.creatorBarbeito, Claudio Gustavo-
dc.date2017-09-14T19:11:51Z-
dc.date2017-09-14T19:11:51Z-
dc.date2013-02-04-
dc.date2017-08-23T20:36:49Z-
dc.date.accessioned2019-04-29T15:52:18Z-
dc.date.available2019-04-29T15:52:18Z-
dc.date.issued2013-02-04-
dc.identifierEöry, M. L.; Zanuzzi, Carolina Natalia; Fuentealba, Nadia Analia; Sguazza, Guillermo Hernán; Gimeno, Eduardo Juan; et al.; Effects of different anesthetics in the murine model of EHV-1 infection; American College of Veterinary Pathologists; Veterinary Pathology; 50; 5; 4-2-2013; 849-856-
dc.identifier0300-9858-
dc.identifierhttp://hdl.handle.net/11336/24283-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/304231-
dc.descriptionMice are commonly used as an experimental model to investigate the Equid herpesvirus 1 (EHV-1) infection. This model easily reproduces the disease, and the clinical signs are more or less similar to those observed in the horse, the natural host. During natural infection, the acute course of respiratory infection is mandatory for the development of adaptive immune response. Since interactions between EHV-1 and anesthetics are possible, the study investigated whether the early events of murine pulmonary immune response could be affected by different anesthetics. Therefore, mice were experimentally infected with a unique EHV-1 strain under the effects of ether, ketamine/xylazine, or isoflurane. Clinical signs and histopathological lesions in the lungs were described, and the cell death and proliferation rates of sham-inoculated or infected animals were quantified using immunohistochemistry. Clinical signs were more severe in animals anesthetized with ether. Qualitative differences in the recruited inflammatory cells were observed following application of anesthesia. The level of infection between the infected groups was not statistically significant. However, lungs from ketamine/xylazine-anesthetized animals showed the highest cell death rates, whereas those from isoflurane-anesthetized animals showed the highest proliferation rates. It has been emphasized that anesthetics alone or their interactions with EHV-1 modify the response against the infection. An appropriate selection of the anesthetic during experimental studies is relevant to minimize wrong conclusions.-
dc.descriptionFil: Eöry, M. L.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina-
dc.descriptionFil: Zanuzzi, Carolina Natalia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Fuentealba, Nadia Analia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Sguazza, Guillermo Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina-
dc.descriptionFil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Galosi, Cecilia Monica. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherAmerican College of Veterinary Pathologists-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/0300985813476062-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/0300985813476062-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectANESTHETICS-
dc.subjectAPOPTOSIS-
dc.subjectEQUID HERPESVIRUS 1-
dc.subjectIMMUNOHISTOCHEMISTRY-
dc.subjectMICE-
dc.subjectPROLIFERATION-
dc.subjectCiencias Veterinarias-
dc.subjectCiencias Veterinarias-
dc.subjectCIENCIAS AGRÍCOLAS-
dc.titleEffects of different anesthetics in the murine model of EHV-1 infection-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
Aparece en las colecciones: CONICET

Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro sencillo del ítem