Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Pinedo Carpio, Edgar | - |
| dc.creator | Davidson, David | - |
| dc.creator | Martinez Marignac, Veronica Lucrecia | - |
| dc.creator | Panasci, Justin | - |
| dc.creator | Aloyz, Raquel | - |
| dc.date | 2018-11-23T22:18:10Z | - |
| dc.date | 2018-11-23T22:18:10Z | - |
| dc.date | 2017-09 | - |
| dc.date | 2018-10-23T20:18:38Z | - |
| dc.date.accessioned | 2019-04-29T15:52:24Z | - |
| dc.date.available | 2019-04-29T15:52:24Z | - |
| dc.date.issued | 2017-09 | - |
| dc.identifier | Pinedo Carpio, Edgar; Davidson, David; Martinez Marignac, Veronica Lucrecia; Panasci, Justin; Aloyz, Raquel; Adaptive metabolic rewiring to chronic SFK inhibition; Impact Journals; OncoTarget; 8; 40; 9-2017; 66758-66768 | - |
| dc.identifier | 1949-2553 | - |
| dc.identifier | http://hdl.handle.net/11336/65101 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/304283 | - |
| dc.description | Src family kinases (SFK) are key regulators of cellular proliferation, differentiation, survival, motility and angiogenesis. As such, SFK inhibitors are being tested in clinical trials to prevent metastasis as an alternative to current treatment regimens for a variety of cancers including breast cancer. To contribute to the development of molecular tools improving SFK-targeted therapies, we used the SFK inhibitor dasatinib and a well characterized triple negative breast cancer cell line (BT20). Comparison of the response of BT20 cells with acquired resistance to dasatinib and its? parental counterpart suggest that chronic exposure to SFK inhibition results in increased dependency on TGFβ signaling for proliferation, both in the absence or the presence of dasatinib. In addition, we found that acquired (but not de novo) resistance to dasatinib was reduced by non-cytotoxic concentrations compounds hindering on PI3K, mTORC1 signaling, endoplasmic reticulum stress or autophagy. | - |
| dc.description | Fil: Pinedo Carpio, Edgar. McGill University; Canadá. Jewish General Hospital; Canadá | - |
| dc.description | Fil: Davidson, David. McGill University; Canadá. Jewish General Hospital; Canadá | - |
| dc.description | Fil: Martinez Marignac, Veronica Lucrecia. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina | - |
| dc.description | Fil: Panasci, Justin. Jewish General Hospital; Canadá. McGill University; Canadá | - |
| dc.description | Fil: Aloyz, Raquel. Jewish General Hospital; Canadá. McGill University; Canadá | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Impact Journals | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.18632/oncotarget.8146 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=8146&path[]=24004 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | METABOLISM | - |
| dc.subject | CANCER | - |
| dc.subject | ADQUIRED RESISTANCE | - |
| dc.subject | PI3K | - |
| dc.subject | SKF INHIBITOR | - |
| dc.subject | TGFB | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Adaptive metabolic rewiring to chronic SFK inhibition | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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