1. RODNA
  2. CONICET
  3. CONICET
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.provenanceCONICET-
dc.creatorRíos Lugo, María J.-
dc.creatorJiménez Ortega, Vanesa-
dc.creatorCano Barquilla, Pilar-
dc.creatorFernández Mateos, Pilar-
dc.creatorSpinedi, Eduardo Julio-
dc.creatorCardinali, Daniel Pedro-
dc.creatorEsquifino, Ana I.-
dc.date2017-01-04T15:19:49Z-
dc.date2017-01-04T15:19:49Z-
dc.date2015-03-
dc.date2016-12-12T14:29:44Z-
dc.date.accessioned2019-04-29T15:53:17Z-
dc.date.available2019-04-29T15:53:17Z-
dc.date.issued2015-03-
dc.identifierRíos Lugo, María J.; Jiménez Ortega, Vanesa; Cano Barquilla, Pilar; Fernández Mateos, Pilar; Spinedi, Eduardo Julio; et al.; Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 21; 3; 3-2015; 175-183-
dc.identifierhttp://hdl.handle.net/11336/10801-
dc.identifier1868-1891-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/304684-
dc.descriptionBackground: Previous studies indicate that the administration of melatonin caused body weight and abdominal visceral fat reductions in rodent models of hyperadiposity. The objective of the present study performed in high-fat fed rats was to evaluate the activity of melatonin on gene expression of some medial basal hypothalamus (MBH) signals involved in feeding behavior regulation, including neuropeptide Y (NPY), proopiomelanocortin (POMC), prolactin-releasing peptide (PrRP), leptin- and insulinreceptors (R) and insulin-R substrate (IRS)-1 and -2. Blood levels of leptin and adiponectin were also measured. Methods: Adult Wistar male rats were divided into four groups (n = 16 per group): (i) control diet (3% fat); (ii) highfat (35%) diet; (iii) high-fat diet+melatonin; (iv) control diet+melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions: (a) tap water; (b) 25 μg/mL of melatonin. Results: After 10 weeks, the high-fat fed rats showed augmented MBH mRNA levels of NPY, leptin-R, PrRP, insulin-R, IRS-1 and IRS-2. The concomitant administration of melatonin counteracted this increase. Feeding of rats with a high-fat diet augmented expression of the MBH POMC gene through an effect insensitive to melatonin treatment. The augmented levels of circulating leptin and adiponectin seen in high-fat fed rats were counteracted by melatonin as was the augmented body weight: melatonin significantly attenuated a body weight increase in highfat fed rats without affecting chow or water consumption. Melatonin augmented plasma leptin and adiponectin in control rats. Conclusions: The results indicate that an effect on gene expression of feeding behavior signals at the central nervous system (CNS) may complement a peripheral rise of the energy expenditure produced by melatonin to decrease body weight in high-fat fed rats.-
dc.descriptionFil: Ríos Lugo, María J.. Universidad Complutense de Madrid. Facultad de Medicina; España-
dc.descriptionFil: Jiménez Ortega, Vanesa. Universidad Complutense de Madrid. Facultad de Medicina; España-
dc.descriptionFil: Cano Barquilla, Pilar. Universidad Complutense de Madrid. Facultad de Medicina; España-
dc.descriptionFil: Fernández Mateos, Pilar. Universidad Complutense de Madrid. Facultad de Medicina; España-
dc.descriptionFil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico la Plata. Centro de Endocrinologia Experimental y Aplicada (i); Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina-
dc.descriptionFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Esquifino, Ana I.. Universidad Complutense de Madrid. Facultad de Medicina; España-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherDe Gruyter-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1515/hmbci-2014-0041-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/hmbci.2015.21.issue-3/hmbci-2014-0041/hmbci-2014-0041.xml-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/10801-
dc.subjectADIPONECTIN-
dc.subjectFOOD INTAKE-
dc.subjectGENE EXPRESSION-
dc.subjectHIGH-FAT DIET-
dc.subjectLEPTIN-
dc.subjectMEDIAL BASAL HYPOTHALAMUS-
dc.subjectMELATONIN-
dc.subjectNEUROPEPTIDE Y-
dc.subjectPROLACTIN-RELEASING PEPTIDE-
dc.subjectPROOPIOMELANOCORTIN-
dc.subjectFarmacología y Farmacia-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleMelatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
Aparece en las colecciones: CONICET

Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro sencillo del ítem