Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Ponzoni, Ignacio | - |
| dc.creator | Nueda, María José | - |
| dc.creator | Tarazona, Sonia | - |
| dc.creator | Götz, Stefan | - |
| dc.creator | Montaner, David | - |
| dc.creator | Dussaut, Julieta Sol | - |
| dc.creator | Dopazo, Joaquín | - |
| dc.creator | Conesa, Ana | - |
| dc.date | 2017-02-03T18:59:16Z | - |
| dc.date | 2017-02-03T18:59:16Z | - |
| dc.date | 2014-03 | - |
| dc.date | 2017-02-02T14:07:25Z | - |
| dc.date.accessioned | 2019-04-29T15:53:45Z | - |
| dc.date.available | 2019-04-29T15:53:45Z | - |
| dc.date.issued | 2014-03 | - |
| dc.identifier | Ponzoni, Ignacio; Nueda, María José; Tarazona, Sonia; Götz, Stefan; Montaner, David; et al.; Pathway network inference from gene expression data; BioMed Central; Bmc Systems Biology; 8; supl. 2; 3-2014; 1-17 | - |
| dc.identifier | 1752-0509 | - |
| dc.identifier | http://hdl.handle.net/11336/12460 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/304888 | - |
| dc.description | Background: The development of high-throughput omics technologies enabled genome-wide measurements of the activity of cellular elements and provides the analytical resources for the progress of the Systems Biology discipline. Analysis and interpretation of gene expression data has evolved from the gene to the pathway and interaction level, i.e. from the detection of differentially expressed genes, to the establishment of gene interaction networks and the identification of enriched functional categories. Still, the understanding of biological systems requires a further level of analysis that addresses the characterization of the interaction between functional modules. Results: We present a novel computational methodology to study the functional interconnections among the molecular elements of a biological system. The PANA approach uses high-throughput genomics measurements and a functional annotation scheme to extract an activity profile from each functional block -or pathway- followed by machine-learning methods to infer the relationships between these functional profiles. The result is a global, interconnected network of pathways that represents the functional cross-talk within the molecular system. We have applied this approach to describe the functional transcriptional connections during the yeast cell cycle and to identify pathways that change their connectivity in a disease condition using an Alzheimer example. Conclusions: PANA is a useful tool to deepen in our understanding of the functional interdependences that operate within complex biological systems. We show the approach is algorithmically consistent and the inferred network is well supported by the available functional data. The method allows the dissection of the molecular basis of the functional connections and we describe the different regulatory mechanisms that explain the network's topology obtained for the yeast cell cycle data. | - |
| dc.description | Fil: Ponzoni, Ignacio. Universidad Nacional del Sur. Departamento de Ciencias e Ingenieria de la Computacion. Laboratorio de Investigación y Desarrollo en Computacion Cientifica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina | - |
| dc.description | Fil: Nueda, María José. Universidad de Alicante; España | - |
| dc.description | Fil: Tarazona, Sonia. Centro de Investigaciones Principe Felipe; España. Universidad de Valencia; España | - |
| dc.description | Fil: Götz, Stefan. Centro de Investigaciones Principe Felipe; España | - |
| dc.description | Fil: Montaner, David. Centro de Investigaciones Principe Felipe; España | - |
| dc.description | Fil: Dussaut, Julieta Sol. Universidad Nacional del Sur. Departamento de Ciencias e Ingenieria de la Computacion. Laboratorio de Investigación y Desarrollo en Computacion Cientifica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Dopazo, Joaquín. Centro de Investigaciones Principe Felipe; España | - |
| dc.description | Fil: Conesa, Ana. Centro de Investigaciones Principe Felipe; España | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | BioMed Central | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S7 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/1752-0509-8-S2-S7 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Pathways | - |
| dc.subject | Pathway Network | - |
| dc.subject | Gene Expression | - |
| dc.subject | Bioinformatics | - |
| dc.subject | Ciencias de la Información y Bioinformática | - |
| dc.subject | Ciencias de la Computación e Información | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Pathway network inference from gene expression data | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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