Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Fernandez, Ariel | - |
| dc.date | 2017-01-30T19:38:25Z | - |
| dc.date | 2017-01-30T19:38:25Z | - |
| dc.date | 2014-09 | - |
| dc.date | 2016-03-21T18:29:05Z | - |
| dc.date.accessioned | 2019-04-29T15:53:58Z | - |
| dc.date.available | 2019-04-29T15:53:58Z | - |
| dc.date.issued | 2014-09 | - |
| dc.identifier | Fernandez, Ariel; Synergizing immunotherapy with molecularly targeted anticancer treatment; Elsevier; Drug Discovery Today; 19; 9; 9-2014; 1427-1432 | - |
| dc.identifier | 1359-6446 | - |
| dc.identifier | http://hdl.handle.net/11336/12172 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/304976 | - |
| dc.description | The therapeutic opportunity for anticancer kinase inhibitors (KIs) that block cell-signaling pathways is materializing. Yet, these molecular-targeted therapies are not tailored to be allies of the immune system, and often antagonize it despite generating antigenic activity. KIs usually offer an incomplete cure and one culprit is the lack of synergy between the drug and the immune system, a problem that is magnified when the therapeutic context involves HIV-1-induced immunosuppression (AIDS). We outline a strategy to fulfill the therapeutic imperative of recruiting cooperative immune responses. Accordingly, we propose a method to redesign anticancer drugs to harness the antigenic products of drug-induced apoptosis of tumor cells, thus eliciting an adjuvant immune response. | - |
| dc.description | Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática; Argentina. Collegium Basilea; Suiza. Ariel Fernández Consultancy; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S135964461400107X | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.drudis.2014.03.022 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Immune System | - |
| dc.subject | Kinase Inhibitor | - |
| dc.subject | Molecular Cancer Therapy | - |
| dc.subject | Biophysics | - |
| dc.subject | Tecnologías que involucran la manipulación de células, tejidos, órganos o todo el organismo | - |
| dc.subject | Biotecnología de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Synergizing immunotherapy with molecularly targeted anticancer treatment | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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