Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Salvarezza, Susana B. | - |
| dc.creator | Lopez, Hector Salvador | - |
| dc.creator | Masco, Daniel Hugo | - |
| dc.date | 2018-12-05T18:28:55Z | - |
| dc.date | 2018-12-05T18:28:55Z | - |
| dc.date | 2003-06 | - |
| dc.date | 2018-11-12T13:45:18Z | - |
| dc.date.accessioned | 2019-04-29T15:53:59Z | - |
| dc.date.available | 2019-04-29T15:53:59Z | - |
| dc.date.issued | 2003-06 | - |
| dc.identifier | Salvarezza, Susana B.; Lopez, Hector Salvador; Masco, Daniel Hugo; The same cellular signaling pathways mediate survival in sensory neurons that switch their trophic requirements during development; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 85; 5; 6-2003; 1347-1358 | - |
| dc.identifier | 0022-3042 | - |
| dc.identifier | http://hdl.handle.net/11336/65890 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/304984 | - |
| dc.description | A distinct subpopulation of rat dorsal root sensory (DRG) neurons, termed P-neurons, switch their trophic requirements for survival during development from nerve growth factor (NGF) at embryonic stages to basic fibroblast growth factor (bFGF) just after birth. We investigated in cultured P-neurons the intracellular signaling pathways mediating survival before and after this switch. The NGF-induced survival was completely blocked by either wortmannin (100 nM) or PD98059 (25-50 nM), which selectively inhibit the phosphatidylinositol 3-kinase-AKT (PI3 kinase-AKT) and mitogen-activated kinase kinase extracellular regulated kinase (MEK-ERKs) pathways, respectively. NGF activated AKT and ERKs in single embryonic P-neurons, as assayed by immunofluorescence of phorphorylated proteins. In concordance with the survival assays, wortmannin and PD98059 blocked AKT and ERKs activation, respectively. Following the trophic switch, bFGF used the same signaling pathways to promote survival of postnatal P-neurons, as either wortmannin or PD98059 blocked its effect. Also, bFGF activated AKT and ERKs in single P-neurons, and this activation was blocked by the same inhibitors. These results strongly suggest that both pathways concurrently mediate the action of NGF and bFGF during embryonic and post-natal periods, respectively. Thus, we report the novel result that the switch in trophic requirements occurs with conservation of the signaling pathways mediating survival. | - |
| dc.description | Fil: Salvarezza, Susana B.. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Biología Celular; Argentina | - |
| dc.description | Fil: Lopez, Hector Salvador. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina | - |
| dc.description | Fil: Masco, Daniel Hugo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Biología Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley Blackwell Publishing, Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1046/j.1471-4159.2003.01771.x | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1046/j.1471-4159.2003.01771.x | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | DORSAL ROOT GANGLION | - |
| dc.subject | MEK-ERKS | - |
| dc.subject | PD98059 | - |
| dc.subject | PI3K-AKT | - |
| dc.subject | SURVIVAL | - |
| dc.subject | WORTMANNIN | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | The same cellular signaling pathways mediate survival in sensory neurons that switch their trophic requirements during development | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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