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dc.creatorBisoffi, Zeno-
dc.creatorBuonfrate, Dora-
dc.creatorSequi, Marco-
dc.creatorMejia, Rojelio-
dc.creatorCimino, Rubén Oscar-
dc.creatorKrolewiecki, Alejandro Javier-
dc.creatorAlbonico, Marco-
dc.creatorGobbo, Maria-
dc.creatorBonafini, Stefania-
dc.creatorAngheben, Andrea-
dc.creatorRequena-Mendez, Ana-
dc.creatorMuñoz, José-
dc.creatorNutman, Thomas B.-
dc.date2018-02-26T18:12:41Z-
dc.date2018-02-26T18:12:41Z-
dc.date2014-01-
dc.date2017-09-01T18:04:18Z-
dc.date.accessioned2019-04-29T15:54:19Z-
dc.date.available2019-04-29T15:54:19Z-
dc.identifierBisoffi, Zeno; Buonfrate, Dora; Sequi, Marco; Mejia, Rojelio; Cimino, Rubén Oscar; et al.; Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection; Public Library of Science; Neglected Tropical Diseases; 8; 1; 1-2014; 1-8; e2640-
dc.identifier1935-2735-
dc.identifierhttp://hdl.handle.net/11336/37122-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305104-
dc.descriptionBackground:The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because of the lack of sensitivity of a fecal-based reference ("gold") standard.Methods:The sensitivity and specificity of 5 serologic tests for S. stercoralis (in-house IFAT, NIE-ELISA and NIE-LIPS and the commercially available Bordier-ELISA and IVD-ELISA) were assessed on 399 cryopreserved serum samples. Accuracy was measured using fecal results as the primary reference standard, but also using a composite reference standard (based on a combination of tests).Results:According to the latter standard, the most sensitive test was IFAT, with 94.6% sensitivity (91.2-96.9), followed by IVD-ELISA (92.3%, 87.7-96.9). The most specific test was NIE-LIPS, with specificity 99.6% (98.9-100), followed by IVD-ELISA (97.4%, 95.5-99.3). NIE-LIPS did not cross-react with any of the specimens from subjects with other parasitic infections. NIE-LIPS and the two commercial ELISAs approach 100% specificity at a cut off level that maintains ≥70% sensitivity.Conclusions:NIE-LIPS is the most accurate serologic test for the diagnosis of S. stercoralis infection. IFAT and each of the ELISA tests are sufficiently accurate, above a given cut off, for diagnosis, prevalence studies and inclusion in clinical trials.-
dc.descriptionFil: Bisoffi, Zeno. Sacro Cuore Hospital; Italia-
dc.descriptionFil: Buonfrate, Dora. Sacro Cuore Hospital; Italia-
dc.descriptionFil: Sequi, Marco. Istituto Di Ricerche Farmacologiche Mario Negri; Italia-
dc.descriptionFil: Mejia, Rojelio. National Institute Of Allergy And Infectious Diseases; Estados Unidos-
dc.descriptionFil: Cimino, Rubén Oscar. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Albonico, Marco. Sacro Cuore Hospital; Italia-
dc.descriptionFil: Gobbo, Maria. Sacro Cuore Hospital; Italia-
dc.descriptionFil: Bonafini, Stefania. Sacro Cuore Hospital; Italia-
dc.descriptionFil: Angheben, Andrea. Sacro Cuore Hospital; Italia-
dc.descriptionFil: Requena-Mendez, Ana. Universidad de Barcelona; España-
dc.descriptionFil: Muñoz, José. Universidad de Barcelona; España-
dc.descriptionFil: Nutman, Thomas B.. National Institute Of Allergy And Infectious Diseases; Estados Unidos-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherPublic Library of Science-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pntd.0002640-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002640-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectSTRONGYLOIDES STERCORALIS-
dc.subjectSEROLOGY-
dc.subjectDIAGNOSTICS-
dc.subjectLIPS-
dc.subjectSalud Ocupacional-
dc.subjectCiencias de la Salud-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleDiagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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