Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Ramirez, Juan | - |
| dc.creator | Rodriguez, Maria Victoria | - |
| dc.creator | Quiroga, Jairo | - |
| dc.creator | Abonia, Rodrigo | - |
| dc.creator | Sortino, Maximiliano Andrés | - |
| dc.creator | Zacchino, Susana Alicia Stella | - |
| dc.creator | Insuasty, Braulio | - |
| dc.date | 2017-12-07T17:14:44Z | - |
| dc.date | 2017-12-07T17:14:44Z | - |
| dc.date | 2014-04 | - |
| dc.date | 2017-12-06T17:01:54Z | - |
| dc.date.accessioned | 2019-04-29T15:54:28Z | - |
| dc.date.available | 2019-04-29T15:54:28Z | - |
| dc.identifier | Ramirez, Juan; Rodriguez, Maria Victoria; Quiroga, Jairo; Abonia, Rodrigo; Sortino, Maximiliano Andrés; et al.; Efficient synthesis under mild reaction conditions of novel 3-aryl-5-(4-chloro-2-morpholinothiazol-5-yl)-4,5-dihydro-1H-pyrazoles and their antifungal activity alone and in combination with commercial antifungal agents.; Wiley VCH Verlag; Archiv Der Pharmazie; 347; 8; 4-2014; 566-575 | - |
| dc.identifier | 0365-6233 | - |
| dc.identifier | http://hdl.handle.net/11336/29968 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305162 | - |
| dc.description | The a,b-unsaturated carbonyl compounds 5a–f were prepared by reaction between 2-chloro-4- morpholinothiazol-5-carbaldehyde 3 and substituted acetophenones 4a–f. Treatment of compounds 5a–f with hydrazine hydrate employing mild reaction conditions led to the formation of 4,5-dihydro- 1H-pyrazoles 6a–f. Then the treatment with acetic anhydride or formic acid afforded the expected 4,5- dihydro-1H-pyrazoles 7a–f and 8a–f. The antifungal activity of each series of synthesized compounds was determined against the clinically important fungi Candida albicans and Cryptococcus neoformans. In addition, the most active compounds 7e and 7f were tested in combination with the commercial antifungal agents: fluconazole, itraconazole, and amphotericin B. Compound 7e showed a synergistic effect with fluconazole against C. albicans while 7f showed synergistic activities with all tested antifungal drugs against the same yeast | - |
| dc.description | Fil: Ramirez, Juan. Universidad del Valle. Fundación Samanea; Colombia | - |
| dc.description | Fil: Rodriguez, Maria Victoria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina | - |
| dc.description | Fil: Quiroga, Jairo. Universidad del Valle. Fundación Samanea; Colombia | - |
| dc.description | Fil: Abonia, Rodrigo. Universidad del Valle. Fundación Samanea; Colombia | - |
| dc.description | Fil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Area Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Area Farmacognosia; Argentina | - |
| dc.description | Fil: Insuasty, Braulio. Universidad del Valle. Fundación Samanea; Colombia | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley VCH Verlag | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ardp.201400084 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ardp.201400084/abstract | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Antifungal activity | - |
| dc.subject | 2-Chloro-4-morpholinothiazol-5-carbaldehyde | - |
| dc.subject | Commercial antifungal agents | - |
| dc.subject | 4,5- Dihydro-1H-pyrazoles | - |
| dc.subject | Synergistic effect | - |
| dc.subject | Otras Ciencias Químicas | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Efficient synthesis under mild reaction conditions of novel 3-aryl-5-(4-chloro-2-morpholinothiazol-5-yl)-4,5-dihydro-1H-pyrazoles and their antifungal activity alone and in combination with commercial antifungal agents. | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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