Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Tonucci, Facundo Mauro | - |
| dc.creator | Hidalgo, Florencia | - |
| dc.creator | Ferretti, Anabela Ferretti | - |
| dc.creator | Almada, Evangelina | - |
| dc.creator | Favre, Cristian | - |
| dc.creator | Goldenring, James R. | - |
| dc.creator | Kaverina, Irina | - |
| dc.creator | Kierbel, Arlinet Verónica | - |
| dc.creator | Larocca, Maria Cecilia | - |
| dc.date | 2016-06-09T16:04:40Z | - |
| dc.date | 2016-06-09T16:04:40Z | - |
| dc.date | 2015-09-01 | - |
| dc.date | 2016-06-07T16:19:30Z | - |
| dc.date.accessioned | 2019-04-29T15:54:44Z | - |
| dc.date.available | 2019-04-29T15:54:44Z | - |
| dc.identifier | Larocca, Maria Cecilia; Kierbel, Arlinet Verónica; Kaverina, Irina; Goldenring, James R.; Favre, Cristian; Almada, Evangelina; et al.; Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells; Company of Biologists; Journal of Cell Science; 128; 17; 1-9-2015; 3277-3289 | - |
| dc.identifier | 0021-9533 | - |
| dc.identifier | http://hdl.handle.net/11336/6121 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305177 | - |
| dc.description | The acquisition of a migratory phenotype is central in processes as diverse as embryo differentiation and tumor metastasis. An early event in this phenomenon is the generation of a nucleus-centrosome-Golgi back to front axis. AKAP350 is a Golgi/centrosome scaffold protein involved in microtubule nucleation. AKAP350 interacts with CIP4, a cdc42 effector that regulates actin dynamics. The present study aimed to characterize the participation of centrosomal AKAP350 in the acquisition of migratory polarity, and the involvement of CIP4 in the pathway. The decrease in total or in centrosomal AKAP350 led to decreased formation of the nucleus-centrosome-Golgi axis and defective cell migration. CIP4 localized at the centrosome. That was enhanced in migratory cells, but inhibited in cells with decreased centrosomal AKAP350. The interference with CIP4 expression or with CIP4/AKAP350 interaction also led to defective cell polarization. Centrosome positioning, but not nuclear movement was affected by loss of CIP4 or AKAP350 function. Our results support a model where AKAP350 recruits CIP4 to the centrosome, providing a centrosomal scaffold to integrate microtubule and actin dynamics, thus enabling centrosome polarization, and ensuring cell migration directionality. | - |
| dc.description | Fil: Tonucci, Facundo Mauro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina | - |
| dc.description | Fil: Hidalgo, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina | - |
| dc.description | Fil: Ferretti, Anabela Ferretti. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina | - |
| dc.description | Fil: Almada, Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina | - |
| dc.description | Fil: Favre, Cristian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina | - |
| dc.description | Fil: Goldenring, James R.. Vanderbilt University. Faculty Of The Medical School; Estados Unidos | - |
| dc.description | Fil: Kaverina, Irina. Vanderbilt University. Faculty Of The Medical School; Estados Unidos | - |
| dc.description | Fil: Kierbel, Arlinet Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); Argentina | - |
| dc.description | Fil: Larocca, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Company of Biologists | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://jcs.biologists.org/content/128/17/3277 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1242/jcs.170878 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/10.1242/jcs.170878 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | CYTOESKELETON | - |
| dc.subject | CELL MIGRATION | - |
| dc.subject | CIP4 | - |
| dc.subject | ACTIN | - |
| dc.subject | Biología Celular, Microbiología | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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