Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Daniotti, Jose Luis | - |
| dc.creator | Lardone, Ricardo Dante | - |
| dc.creator | Vilcaes, Aldo Alejandro | - |
| dc.date | 2018-07-12T18:08:27Z | - |
| dc.date | 2018-07-12T18:08:27Z | - |
| dc.date | 2016-01-07 | - |
| dc.date | 2018-06-29T16:45:49Z | - |
| dc.date.accessioned | 2019-04-29T15:54:56Z | - |
| dc.date.available | 2019-04-29T15:54:56Z | - |
| dc.identifier | Daniotti, Jose Luis; Lardone, Ricardo Dante; Vilcaes, Aldo Alejandro; Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents; Frontiers Research Foundation; Frontiers in Oncology; 5; 7-1-2016; 300-300 | - |
| dc.identifier | http://hdl.handle.net/11336/51890 | - |
| dc.identifier | 2234-943X | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305246 | - |
| dc.description | Glycolipids are complex molecules consisting of a ceramide lipid moiety linked to a glycan chain of variable length and structure. Among these are found the gangliosides, which are sialylated glycolipids ubiquitously distributed on the outer layer of vertebrate plasma membranes. Changes in the expression of certain species of gangliosides have been described to occur during cell proliferation, differentiation, and ontogenesis. However, the aberrant and elevated expression of gangliosides has been also observed in different types of cancer cells, thereby promoting tumor survival. Moreover, gangliosides are actively released from the membrane of tumor cells, having a strong impact on impairing anti-tumor immunity. Beyond the undesirable effects of gangliosides in cancer cells, a substantial number of cancer immunotherapies have been developed in recent years that have used gangliosides as the main target. This has resulted in successful immune cell- or antibody-responses against glycolipids, with promising results having been obtained in clinical trials. In this review, we provide a general overview on the metabolism of glycolipids, both in normal and tumor cells, as well as examining glycolipid-mediated immune modulation and the main successes achieved in immunotherapies using gangliosides as molecular targets. | - |
| dc.description | Fil: Daniotti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina | - |
| dc.description | Fil: Lardone, Ricardo Dante. The John Wayne Cancer Institute; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Vilcaes, Aldo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Frontiers Research Foundation | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fonc.2015.00300 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fonc.2015.00300/full | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ANTIBODIES | - |
| dc.subject | CANCER | - |
| dc.subject | GANGLIOSIDES | - |
| dc.subject | GLYCOLIPIDS | - |
| dc.subject | IMMUNOTHERAPY | - |
| dc.subject | IMMUNOTOXIN | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Dysregulated expression of glycolipids in tumor cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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