Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Bernis, Maria Eugenia | - |
| dc.creator | Oksdath, Mariana | - |
| dc.creator | Dupraz, Sebastian, Enrique | - |
| dc.creator | Nieto Guil, Alvaro Fernando | - |
| dc.creator | Fernández, Marisa Mariel | - |
| dc.creator | Malchiodi, Emilio Luis | - |
| dc.creator | Rosso, Silvana Beatriz | - |
| dc.creator | Quiroga, Santiago | - |
| dc.date | 2016-11-08T19:17:10Z | - |
| dc.date | 2016-11-08T19:17:10Z | - |
| dc.date | 2013-10 | - |
| dc.date | 2016-11-07T15:39:26Z | - |
| dc.date.accessioned | 2019-04-29T15:55:15Z | - |
| dc.date.available | 2019-04-29T15:55:15Z | - |
| dc.identifier | Bernis, Maria Eugenia; Oksdath, Mariana; Dupraz, Sebastian, Enrique; Nieto Guil, Alvaro Fernando; Fernández, Marisa Mariel; et al.; Wingless-type family member 3A (Wnt3a) triggers polarization of hippocampal neurons via cross-activation of the IGF-1 receptor/PI3k pathway; Frontiers Research Foundation; Front Cell Neurosci; 7; 194; 10-2013; 1-12 | - |
| dc.identifier | http://hdl.handle.net/11336/8066 | - |
| dc.identifier | 1662-5102 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305358 | - |
| dc.description | Initial axonal elongation is essential for neuronal polarization and requires polarized activation of IGF-1 receptors (IGF-1r) and the phosphatidylinositol 3 kinase (PI3k) pathway. Wingless-type family growth factors (Wnts) have also been implied in the regulation of axonal development. It is not known, however, if Wnts have any participation in the regulation of initial axonal outgrowth and the establishment of neuronal polarity. We used cultured hippocampal neurons and growth cone particles (GCPs) isolated from fetal rat brain to show that stimulation with the wingless family factor 3A (Wnt3a) was sufficient to promote neuronal polarization in the absence of IGF-1 or high insulin. We also show that Wnt3a triggered a strong activation of IGF-1r, PI3k, and Akt in developmental Stage 2 neurons and that the presence of activatable IGF-1r and PI3k activation were necessary for Wnt3a polarizing effects. Surface plasmon resonance (SPR) experiments show that Wnt3a did not bind specifically to the IGF-1r. Using crosslinking and immuno-precipitation experiments, we show that stimulation with Wnt3a triggered the formation of a complex including IGF-1r-Wnt3a-Frizzled-7. We conclude that Wnt3a triggers polarization of neurons via cross-activation of the IGF-1r/PI3k pathway upon binding to Fz7. | - |
| dc.description | Fil: Bernis, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); Argentina | - |
| dc.description | Fil: Oksdath, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); Argentina | - |
| dc.description | Fil: Dupraz, Sebastian, Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); Argentina | - |
| dc.description | Fil: Nieto Guil, Alvaro Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); Argentina | - |
| dc.description | Fil: Fernández, Marisa Mariel. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina | - |
| dc.description | Fil: Malchiodi, Emilio Luis. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina | - |
| dc.description | Fil: Rosso, Silvana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); Argentina | - |
| dc.description | Fil: Quiroga, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Frontiers Research Foundation | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fncel.2013.00194/full | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fncel.2013.00194 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829478/ | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | WNT3A | - |
| dc.subject | IGF-1 RECEPTOR | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Wingless-type family member 3A (Wnt3a) triggers polarization of hippocampal neurons via cross-activation of the IGF-1 receptor/PI3k pathway | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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