Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Sequeira, Gonzalo Ricardo | - |
| dc.creator | Vanzulli, Silvia I. | - |
| dc.creator | Rojas, Paola Andrea | - |
| dc.creator | Lamb, Caroline Ana | - |
| dc.creator | Colombo, Lucas Luis | - |
| dc.creator | May, Maria | - |
| dc.creator | Molinolo, Alfredo | - |
| dc.creator | Lanari, Claudia Lee Malvina | - |
| dc.date | 2016-07-01T16:20:23Z | - |
| dc.date | 2016-07-01T16:20:23Z | - |
| dc.date | 2014-04-27 | - |
| dc.date | 2016-06-15T19:12:03Z | - |
| dc.date.accessioned | 2019-04-29T15:55:24Z | - |
| dc.date.available | 2019-04-29T15:55:24Z | - |
| dc.identifier | Sequeira, Gonzalo Ricardo; Vanzulli, Silvia I.; Rojas, Paola Andrea; Lamb, Caroline Ana; Colombo, Lucas Luis; et al.; The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer; Impact Journals; Oncotarget; 5; 10; 27-4-2014; 3246-3260 | - |
| dc.identifier | http://hdl.handle.net/11336/6289 | - |
| dc.identifier | 1949-2553 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305421 | - |
| dc.description | There is clinical and experimental evidence suggesting that antiprogestins might be used for the treatment of selected breast cancer patients. Our aim was to evaluate the effect of albumin-bound paclitaxel (Nab-paclitaxel) and pegylated doxorubicin liposomes (PEG-LD) in combination with mifepristone (MFP) in experimental breast cancer models expressing different ratios of progesterone receptor (PR) isoforms A and B. We used two antiprogestin-responsive (PRA>PRB) and two resistant (PRA<PRB) murine mammary carcinomas growing in BALB/c, GFP-BALB/c or nude mice, along with human T47D-YA and T47D-YB xenografts growing in immunocompromised NSG mice. MFP improved the therapeutic effects of suboptimal doses of Nab-paclitaxel or PEG-LD in murine and human carcinomas with higher levels of PRA than PRB. MFP induced tissue remodeling in PRA-overexpressing tumors, increasing the stromal/tumor cell ratio and the number of functional vessels. Accordingly, an increase in nanoparticles and drug accumulation was observed in stromal and tumor cells in MFP-treated tumors. We conclude that MFP induces an increase in vessels during tissue remodeling, favoring the selective accumulation of nanoparticles inside the tumors. We propose that antiprogestins have the potential to enhance the efficacy of chemotherapy in breast tumors with a high PRA/PRB ratio. | - |
| dc.description | Fil: Sequeira, Gonzalo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina | - |
| dc.description | Fil: Vanzulli, Silvia I.. Academia Nacional de Medicina de Buenos Aires; Argentina | - |
| dc.description | Fil: Rojas, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina | - |
| dc.description | Fil: Lamb, Caroline Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina | - |
| dc.description | Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "angel H. Roffo"; Argentina | - |
| dc.description | Fil: May, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina | - |
| dc.description | Fil: Molinolo, Alfredo. National Institutes of Health. National Institute of Dental and Craniofacial Research. Oral and Phayngeal Cancer Branch; Estados Unidos | - |
| dc.description | Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Impact Journals | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/10.18632/oncotarget.1922 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://doi.org/10.18632/oncotarget.1922 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/pmid/PMC4102807 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=1922 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102807/ | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | BREAST CANCER | - |
| dc.subject | PR ISOFORMS | - |
| dc.subject | DOXORUBICIN | - |
| dc.subject | PACLITAXEL | - |
| dc.subject | MIFEPRISTONE | - |
| dc.subject | MAMMARY CARCINOMAS | - |
| dc.subject | NAB-PACLITAXEL | - |
| dc.subject | PEGYLATED DOXORUBICIN LIPOSOMES | - |
| dc.subject | Patología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.subject | Oncología | - |
| dc.subject | Medicina Clínica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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