Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Cuestas, María Luján | - |
| dc.creator | Mathet, Veronica Lidia | - |
| dc.creator | Oubiña, Jose Raul | - |
| dc.creator | Sosnik, Alejandro Dario | - |
| dc.date | 2019-01-08T19:05:59Z | - |
| dc.date | 2019-01-08T19:05:59Z | - |
| dc.date | 2010-07 | - |
| dc.date | 2019-01-07T13:34:57Z | - |
| dc.date.accessioned | 2019-04-29T15:55:39Z | - |
| dc.date.available | 2019-04-29T15:55:39Z | - |
| dc.identifier | Cuestas, María Luján; Mathet, Veronica Lidia; Oubiña, Jose Raul; Sosnik, Alejandro Dario; Drug delivery systems and liver targeting for the improved pharmacotherapy of the hepatitis B virus (HBV) infection; Springer/Plenum Publishers; Pharmaceutical Research; 27; 7; 7-2010; 1184-1202 | - |
| dc.identifier | 0724-8741 | - |
| dc.identifier | http://hdl.handle.net/11336/67674 | - |
| dc.identifier | 1573-904X | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305520 | - |
| dc.description | In spite of the progress made in vaccine and antiviral therapy development, hepatitis B virus (HBV) infection is still the most common cause of liver cirrhosis and hepatocellular carcinoma, with more than 400 million people chronically infected worldwide. Antiviral therapy with nucleos(t)ide analogues and/or immunomodulating peptides is the only option to control and prevent the progression of the disease in chronic hepatitis B (CHB)-infected patients. So far, the current antiviral monotherapy remains unsatisfactory because of the low efficacy and the development of drug resistance mutants. Moreover, viral rebound is frequently observed following therapy cessation, since covalent closed circular DNA (cccDNA) is not removed from hepatocytes by antiviral therapy. First, this review describes the current pharmacotherapy for the management of CHB and the new drug candidates being investigated. Then, the challenges in the development of drug delivery systems for the targeting of antiviral drugs to the liver parenchyma are discussed. Finally, perspectives in the design of a more efficient pharmacotherapy to eradicate the virus from the host are addressed. | - |
| dc.description | Fil: Cuestas, María Luján. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Area Virologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Mathet, Veronica Lidia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Area Virologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Oubiña, Jose Raul. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Area Virologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Springer/Plenum Publishers | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11095-010-0112-z | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11095-010-0112-z | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ANTIVIRAL PHARMACOTHERAPY | - |
| dc.subject | DRUG DELIVERY SYSTEMS | - |
| dc.subject | HEPATITIS B VIRUS (HBV) | - |
| dc.subject | LIVER TARGETING | - |
| dc.subject | NANOTECHNOLOGY | - |
| dc.subject | Otras Nanotecnología | - |
| dc.subject | Nanotecnología | - |
| dc.subject | INGENIERÍAS Y TECNOLOGÍAS | - |
| dc.title | Drug delivery systems and liver targeting for the improved pharmacotherapy of the hepatitis B virus (HBV) infection | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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