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dc.creatorde la Torre, José M.-
dc.creatorNogueras, Manuel-
dc.creatorBorkowski, Eduardo Jorge-
dc.creatorSuvire, Fernando D.-
dc.creatorEnriz, Ricardo Daniel-
dc.creatorCobo, Justo-
dc.date2017-03-31T19:18:55Z-
dc.date2017-03-31T19:18:55Z-
dc.date2014-04-
dc.date2016-11-24T19:23:45Z-
dc.date.accessioned2019-04-29T15:55:51Z-
dc.date.available2019-04-29T15:55:51Z-
dc.identifierde la Torre, José M.; Nogueras, Manuel; Borkowski, Eduardo Jorge; Suvire, Fernando D.; Enriz, Ricardo Daniel; et al.; Easy synthesis of new series of pteridine analogs: di- and tetra-hydropyrimido[4,5-d]pyrimidines via 5-pyrimidinecarbaldehydes; Arkat USA; Arkivoc - Archive for Organic Chemistry; 2014; 5; 4-2014; 42-63-
dc.identifier1551-7004-
dc.identifierhttp://hdl.handle.net/11336/14627-
dc.identifier1551-7012-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305596-
dc.descriptionPyrimidine-5-carbaldehyde derivatives, of easy access, were selected as precursors for the synthesis of mimic pteridine derivatives 5,6-dihydropyrimido[4,5-d]pyrimidines and 5,6,7,8- tetrahydropyrimido[4,5-d]pyrimidines via 4-amino-(5-aminomethyl)pyrimidine intermediates. Straightforward procedures allow a quick access to these compounds. The dihydro derivatives were prepared means of a final cyclocondensation carried out with orthoesters, catalysed by acid and assisted by microwaves irradiation under solvent free conditions. The final cyclocondensation with carbonyl compounds forming the tetrahydro derivatives was done under mild conditions, in which stereochemical induction was carried out on the building of this skeleton, and stereochemistry assignments corroborated by theoretical calculations.-
dc.descriptionFil: de la Torre, José M.. Universidad de Jaén; España-
dc.descriptionFil: Nogueras, Manuel. Universidad de Jaén; España-
dc.descriptionFil: Borkowski, Eduardo Jorge. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Suvire, Fernando D.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina-
dc.descriptionFil: Enriz, Ricardo Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Cobo, Justo. Universidad de Jaén; España-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherArkat USA-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://quod.lib.umich.edu/a/ark/5550190.p008.653/1-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.3998/ark.5550190.p008.653-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subject4-Amino-5-(aminomethyl)pyrimidines-
dc.subjectMicrowave irradiation; ; ; cyclocondensation;-
dc.subjectTheoretical calculations-
dc.subjectAcid catalysis-
dc.subjectCyclocondensation-
dc.subjectStereoselectivity-
dc.subjectQuímica Orgánica-
dc.subjectCiencias Químicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleEasy synthesis of new series of pteridine analogs: di- and tetra-hydropyrimido[4,5-d]pyrimidines via 5-pyrimidinecarbaldehydes-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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