Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Revsin, Yanina | - |
| dc.creator | Saravia, Flavia Eugenia | - |
| dc.creator | Roig, Paulina | - |
| dc.creator | Lima, Analia Ethel | - |
| dc.creator | de Kloet, E. Ronald | - |
| dc.creator | Homo Delarche, Francoise | - |
| dc.creator | de Nicola, Alejandro Federico | - |
| dc.date | 2018-02-09T01:37:09Z | - |
| dc.date | 2018-02-09T01:37:09Z | - |
| dc.date | 2005-03 | - |
| dc.date | 2017-12-28T13:42:05Z | - |
| dc.date.accessioned | 2019-04-29T15:56:01Z | - |
| dc.date.available | 2019-04-29T15:56:01Z | - |
| dc.identifier | Revsin, Yanina; Saravia, Flavia Eugenia; Roig, Paulina; Lima, Analia Ethel; de Kloet, E. Ronald; et al.; Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes; Elsevier Science; Brain Research; 1038; 1; 3-2005; 22-31 | - |
| dc.identifier | 0006-8993 | - |
| dc.identifier | http://hdl.handle.net/11336/36272 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305669 | - |
| dc.description | The influence of diabetes mellitus on brain pathology is increasingly recognized. Previous contributions of our laboratory demonstrated in models of type 1 diabetes (nonobese diabetic and streptozotocin (STZ)-treated mice), a marked astrogliosis and neurogenesis deficit in hippocampus and increased expression of hypothalamic neuropeptides. In the present investigation, we further analyzed alterations of astroglia and neurons in the hippocampus of mice 1 month after STZ-induced diabetes. Results showed that these STZ-diabetic mice presented: (a) increased number of astrocytes positive for apolipoprotein-E (Apo-E), a marker of ongoing neuronal dysfunction; (b) abnormal expression of early gene products associated with neuronal activation, including a high number of Jun + neurons in CA1 and CA3 layers and dentate gyrus, and of Fos-expressing neurons in CA3 layer; (c) augmented activity of NADPH-diaphorase, linked to oxidative stress, in CA3 region. These data support the concept that uncontrolled diabetes leads to hippocampal pathology, which adjoin to changes in other brain structures such as hypothalamus and cerebral cortex. | - |
| dc.description | Fil: Revsin, Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina | - |
| dc.description | Fil: Roig, Paulina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Lima, Analia Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: de Kloet, E. Ronald. Leiden University; Países Bajos | - |
| dc.description | Fil: Homo Delarche, Francoise. Inserm; Francia | - |
| dc.description | Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Science | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0006899304019584?via%3Dihub | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.brainres.2004.12.032 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/pmid/15748869 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ASTROCYTES | - |
| dc.subject | DIABETES MELLITUS | - |
| dc.subject | HIPPOCAMPUS | - |
| dc.subject | NEURONS | - |
| dc.subject | PROTO ONCOGENE PROTEINS | - |
| dc.subject | Neurociencias | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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