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dc.creatorSegovia, M.-
dc.creatorLouvet, C.-
dc.creatorCharnet, P.-
dc.creatorSavina, A.-
dc.creatorTilly, G.-
dc.creatorGautreau, L.-
dc.creatorCarretero-Iglesia, L.-
dc.creatorBeriou, G.-
dc.creatorCebrián, José Ignacio-
dc.creatorCens, T.-
dc.creatorHepburn, L.-
dc.creatorChiffoleau, E.-
dc.creatorFloto, R. A.-
dc.creatorAnegon, I.-
dc.creatorAmigorena, S.-
dc.creatorHill, M.-
dc.creatorCuturi, M. C.-
dc.date2017-12-19T15:28:59Z-
dc.date2017-12-19T15:28:59Z-
dc.date2014-04-14-
dc.date2017-11-09T13:34:23Z-
dc.date.accessioned2019-04-29T15:56:06Z-
dc.date.available2019-04-29T15:56:06Z-
dc.identifierCuturi, M. C.; Hill, M.; Amigorena, S.; Anegon, I.; Floto, R. A.; Chiffoleau, E.; et al.; Autologous dendritic cells prolong allograft survival through tmem176b-dependent antigen cross-presentation; Wiley Blackwell Publishing, Inc; American Journal of Transplantation; 14; 14-4-2014; 1021-1031-
dc.identifier1600-6135-
dc.identifierhttp://hdl.handle.net/11336/31016-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305704-
dc.descriptionThe administration of autologous (recipient-derived) tolerogenic dendritic cells (ATDCs) is under clinical evaluation. However, the molecular mechanisms by which these cells prolong graft survival in a donor-specific manner is unknown. Here, we tested mouse ATDCs for their therapeutic potential in a skin transplantation model. ATDC injection in combination with anti-CD3 treatment induced the accumulation of CD8(+) CD11c(+) T cells and significantly prolonged allograft survival. TMEM176B is an intracellular protein expressed in ATDCs and initially identified in allograft tolerance. We show that Tmem176b(-/-) ATDCs completely failed to trigger both phenomena but recovered their effect when loaded with donor peptides before injection. These results strongly suggested that ATDCs require TMEM176B to cross-present antigens in a tolerogenic fashion. In agreement with this, Tmem176b(-/-) ATDCs specifically failed to cross-present male antigens or ovalbumin to CD8(+) T cells. Finally, we observed that a Tmem176b-dependent cation current controls phagosomal pH, a critical parameter in cross-presentation. Thus, ATDCs require TMEM176B to cross-present donor antigens to induce donor-specific CD8(+) CD11c(+) T cells with regulatory properties and prolong graft survival.-
dc.descriptionFil: Segovia, M.. Center for Research inTransplantation and Immunology; Francia-
dc.descriptionFil: Louvet, C.. Center for Research inTransplantation and Immunology; Francia-
dc.descriptionFil: Charnet, P.. Centre de Recherche en Biologie cellulaire de Montpellier; Francia-
dc.descriptionFil: Savina, A.. Institut Curie; Francia. INSERM; Francia-
dc.descriptionFil: Tilly, G.. Center for Research inTransplantation and Immunology; Francia-
dc.descriptionFil: Gautreau, L.. Center for Research inTransplantation and Immunology; Francia-
dc.descriptionFil: Carretero-Iglesia, L.. Center for Research inTransplantation and Immunology; Francia-
dc.descriptionFil: Beriou, G.. Center for Research inTransplantation and Immunology; Francia-
dc.descriptionFil: Cebrián, José Ignacio. Institut Curie, Inserm U932, Immunité Et Cancer; . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina-
dc.descriptionFil: Cens, T.. Centre de Recherche en Biologie cellulaire de Montpellier; Francia-
dc.descriptionFil: Hepburn, L.. University of Cambridge. Cambridge Institute for Medical Research, Department of Medicine, ; Reino Unido-
dc.descriptionFil: Chiffoleau, E.. Center for Research inTransplantation and Immunology; Francia-
dc.descriptionFil: Floto, R. A.. University of Cambridge. Cambridge Institute for Medical Research, Department of Medicine, ; Reino Unido. Center for Research inTransplantation and Immunology; Francia-
dc.descriptionFil: Anegon, I.. Center for Research inTransplantation and Immunology; Francia-
dc.descriptionFil: Amigorena, S.. Institut Curie; Francia. INSERM; Francia-
dc.descriptionFil: Hill, M.. Center for Research inTransplantation and Immunology; Francia-
dc.descriptionFil: Cuturi, M. C.. Center for Research inTransplantation and Immunology; Francia-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherWiley Blackwell Publishing, Inc-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com.gate2.inist.fr/doi/10.1111/ajt.12708/abstract-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/ajt.12708-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectAUTOLOGOUS DENDRITIC CELLS-
dc.subjectCELLULAR THERAPY-
dc.subjectCROSS-PRESENTATION-
dc.subjectION CHANNEL-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleAutologous dendritic cells prolong allograft survival through tmem176b-dependent antigen cross-presentation-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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