Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Aiello, Ernesto Alejandro | - |
| dc.creator | Casey, Joseph R. | - |
| dc.creator | Alvarez, Bernardo | - |
| dc.date | 2018-06-20T01:32:09Z | - |
| dc.date | 2018-06-20T01:32:09Z | - |
| dc.date | 2017-10 | - |
| dc.date | 2018-06-08T14:28:16Z | - |
| dc.date.accessioned | 2019-04-29T15:56:31Z | - |
| dc.date.available | 2019-04-29T15:56:31Z | - |
| dc.identifier | Aiello, Ernesto Alejandro; Casey, Joseph R.; Alvarez, Bernardo; Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential; Lippincott Williams; Circulation-arrhythmia And Electrophysiology; 10; 10; 10-2017; 1-3 | - |
| dc.identifier | 1941-3149 | - |
| dc.identifier | http://hdl.handle.net/11336/49489 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305828 | - |
| dc.description | Regulation of intracellular pH (pHi) is often considered a ?housekeeping? function, contributing little to cardiac function. With the study published by Sirish et al7 in this issue of Circulation: Arrhythmia and Electrophysiology, a Cl-/HCO3- exchanger is revealed to have a more central role in cardiac function.Intracellular pH is an important modulator of cardiac excitation and contraction1, and adversely contributes to electrical arrhythmia2. Cardiac myocytes express a complex apparatus to regulate pHi. Cardiac muscle cytosolic pH (~7.2) is maintained by sarcolemmal ion transport proteins that move H+, OH− or HCO3− ions across the membrane3. Along with the acid extruders Na+/H+ exchanger (NHE1) and Na+/HCO3− cotransporter (NBC, electrogenic NBCe1/e2 and electroneutral NBCn1) myocytes possess Cl-/HCO3− exchangers (SLC4 family members AE1, AE2, and AE3) and Cl-/OH- exchanger (CHE, with no molecular identity) alkali extruders3. SLC26 gene family members were identified as (mouse slc26a64 and its human orthologue SLC26A65, and slc26a36) responsible for Cl-/HCO3− and Cl-/OH- at plasma membrane of heart ventricles6. The work of Sirish et al7 in this issue revealed that ablation of slc26a6, a plasma membrane Cl-/HCO3- exchange protein, results in cardiac action potential (AP) shortening, cardiomyocyte Ca2+ transient (CaT) and sarcoplasmic reticulum (SR) Ca2+ load reduction, cardiomyocyte diminution of sarcomeric shortening, and cardiomyocyte intracellular pH (pHi) elevation. Moreover, in slc26a6-/- mice these factors led to a reduction of cardiac fractional shortening and cardiac contractility responses, and alterations of cardiac conduction system, as seen in sinus bradycardia and fragmentation of the QRS electrocardiographic-recorded complex. Since slc26a6 has stoichiometry of 2 (or more) HCO3-: Cl-, its transport function is electrogenic, with significance to the cardiomyocyte membrane potential. | - |
| dc.description | Fil: Aiello, Ernesto Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; Argentina | - |
| dc.description | Fil: Casey, Joseph R.. University Of Alberta. Faculty Of Medicine And Oral Health Sciences; Canadá | - |
| dc.description | Fil: Alvarez, Bernardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Lippincott Williams | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://circep.ahajournals.org/content/10/10/e005812.long | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1161/CIRCEP.117.005812 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/pmid/29025770 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ACTION POTENTIALS | - |
| dc.subject | ION TRANSPORT | - |
| dc.subject | PHYSIOLOGY | - |
| dc.subject | SARCOPLASMATIC RETICULUM | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.subject | Fisiología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Cl−/HCO3− Exchanger slc26a6: a ph regulator shapes the cardiac action potential | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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