Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Kivlehan, Francine | - |
| dc.creator | Garay, Fernando Sebastian | - |
| dc.creator | Guo, Jidong | - |
| dc.creator | Chaum, Edward | - |
| dc.creator | Lindner, Ernö | - |
| dc.date | 2018-10-09T16:34:25Z | - |
| dc.date | 2018-10-09T16:34:25Z | - |
| dc.date | 2012-09 | - |
| dc.date | 2018-09-18T16:14:57Z | - |
| dc.date.accessioned | 2019-04-29T15:56:54Z | - |
| dc.date.available | 2019-04-29T15:56:54Z | - |
| dc.identifier | Kivlehan, Francine; Garay, Fernando Sebastian; Guo, Jidong; Chaum, Edward; Lindner, Ernö; Toward feedback-controlled anesthesia: Voltammetric measurement of propofol (2,6-diisopropylphenol) in serum-like electrolyte solutions; American Chemical Society; Analytical Chemistry; 84; 18; 9-2012; 7670-7676 | - |
| dc.identifier | 0003-2700 | - |
| dc.identifier | http://hdl.handle.net/11336/61960 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305986 | - |
| dc.description | Propofol is a widely used, potent intravenous anesthetic for ambulatory anesthesia and long-term sedation. The target steady state concentration of propofol in blood is 0.25-10 μg/mL (1-60 μM). Although propofol can be oxidized electrochemically, monitoring its concentration in biological matrixes is very challenging due to (i) low therapeutic concentration, (ii) high concentrations of easily oxidizable interfering compounds in the sample, and (iii) fouling of the working electrode. In this work we report the performance characteristics of an organic film coated glassy carbon (GC) electrode for continuous monitoring of propofol. The organic film (a plasticized PVC membrane) improved the detection limit and the selectivity of the voltammetric sensor due to the large difference in hydrophobicity between the analyte (propofol) and interfering compounds of the sample, e.g., ascorbic acid (AA) or p-acetamidophenol (APAP). Furthermore, the membrane coating prevented electrode fouling and served as a protective barrier against electrode passivation by proteins. Studies revealed that sensitivity and selectivity of the voltammetric method is greatly influenced by the composition of the PVC membrane. The detection limit of the membrane-coated sensor for propofol in PBS is reported as 0.03 ± 0.01 μM. In serum-like electrolyte solutions containing physiologically relevant levels of albumin (5%) and 3 mM AA and 1 mM APAP as interfering agents, the detection limit was 0.5 ± 0.4 μM. Both values are below the target concentrations used clinically during anesthesia or sedation. © 2012 American Chemical Society. | - |
| dc.description | Fil: Kivlehan, Francine. University of Memphis; Estados Unidos | - |
| dc.description | Fil: Garay, Fernando Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina | - |
| dc.description | Fil: Guo, Jidong. University of Memphis; Estados Unidos | - |
| dc.description | Fil: Chaum, Edward. University of Tennessee; Estados Unidos | - |
| dc.description | Fil: Lindner, Ernö. University of Memphis; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Chemical Society | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1021/ac3006878 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/ac3006878 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Propofol | - |
| dc.subject | Membrane-coated sensor | - |
| dc.subject | Passivation | - |
| dc.subject | Voltammetry | - |
| dc.subject | Otras Ciencias Químicas | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Toward feedback-controlled anesthesia: Voltammetric measurement of propofol (2,6-diisopropylphenol) in serum-like electrolyte solutions | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.