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Campo DC Valor Lengua/Idioma
dc.creatorJacovas, Vanessa Cristina-
dc.creatorRovaris, Diego Luiz-
dc.creatorPerez, Luis Orlando-
dc.creatorde Azevedo, Soledad-
dc.creatorSouza Macedo, Gabriel-
dc.creatorSandoval, José Raul-
dc.creatorSalazar Granara, Alberto-
dc.creatorVillena, Mercedes-
dc.creatorDugoujon, Jean Michel-
dc.creatorBisso Machado, Rafael-
dc.creatorPetzl Erler, Maria Luiza-
dc.creatorSalzano, Francisco Mauro-
dc.creatorAshton Prolla, Patrícia-
dc.creatorRamallo, Virginia-
dc.creatorBortolini, Maria Catira-
dc.date2018-05-08T14:44:37Z-
dc.date2018-05-08T14:44:37Z-
dc.date2015-09-
dc.date2018-05-02T18:13:31Z-
dc.date.accessioned2019-04-29T15:57:06Z-
dc.date.available2019-04-29T15:57:06Z-
dc.identifierJacovas, Vanessa Cristina; Rovaris, Diego Luiz; Perez, Luis Orlando; de Azevedo, Soledad; Souza Macedo, Gabriel; et al.; Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes; Public Library of Science; Plos One; 10; 9; 9-2015; 1-15-
dc.identifier1932-6203-
dc.identifierhttp://hdl.handle.net/11336/44404-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/306063-
dc.descriptionThe diversity of the five single nucleotide polymorphisms located in genes of the TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and LIF, rs929271) were studied in a total of 282 individuals belonging to Quechua, Aymara, Chivay, Cabanaconde, Yanke, Taquile, Amantani, Anapia, Uros, Guarani Ñandeva, and Guarani Kaiowá populations, characterized as Native American or as having a high level (> 90%) of Native American ancestry. In addition, published data pertaining to 100 persons from five other Native American populations (Surui, Karitiana, Maya, Pima, and Piapoco) were analyzed. The populations were classified as living in high altitude (≥ 2,500 m) or in lowlands (< 2,500 m). Our analyses revealed that alleles USP7-G, LIF-T, and MDM2-T showed significant evidence that they were selected for in relation to harsh environmental variables related to high altitudes. Our results show for the first time that alleles of classical TP53 network genes have been evolutionary co-opted for the successful human colonization of the Andes.-
dc.descriptionFil: Jacovas, Vanessa Cristina. Universidade Federal do Rio Grande do Sul; Brasil-
dc.descriptionFil: Rovaris, Diego Luiz. Universidade Federal do Rio Grande do Sul; Brasil-
dc.descriptionFil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Souza Macedo, Gabriel. Universidade Federal do Rio Grande do Sul; Brasil-
dc.descriptionFil: Sandoval, José Raul. Universidad de San Martin de Porres; Perú-
dc.descriptionFil: Salazar Granara, Alberto. Universidad de San Martin de Porres; Perú-
dc.descriptionFil: Villena, Mercedes. Universidad Mayor de San Andrés; Bolivia-
dc.descriptionFil: Dugoujon, Jean Michel. Université Paul Sabatier Toulouse III; Francia-
dc.descriptionFil: Bisso Machado, Rafael. Universidade Federal do Rio Grande do Sul; Brasil-
dc.descriptionFil: Petzl Erler, Maria Luiza. Universidade Federal do Paraná; Brasil-
dc.descriptionFil: Salzano, Francisco Mauro. Universidade Federal do Rio Grande do Sul; Brasil-
dc.descriptionFil: Ashton Prolla, Patrícia. Universidade Federal do Rio Grande do Sul; Brasil. Hospital de Clínicas de Porto Alegre; Brasil-
dc.descriptionFil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherPublic Library of Science-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1371/journal.pone.0137823-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137823-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectTP53 PATHWAY-
dc.subjectHUMAN ADAPTATION HIGH ALTITUDE-
dc.subjectNATIVE AMERICAN-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleGenetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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