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dc.creatorByk, Laura Andrea-
dc.creatorGamarnik, Andrea Vanesa-
dc.date2017-06-14T19:13:44Z-
dc.date2017-06-14T19:13:44Z-
dc.date2016-09-
dc.date2017-06-12T21:00:13Z-
dc.date.accessioned2019-04-29T15:57:27Z-
dc.date.available2019-04-29T15:57:27Z-
dc.identifierByk, Laura Andrea; Gamarnik, Andrea Vanesa; Properties and Functions of the Dengue Virus Capsid Protein; Annual Reviews; Annual Review of Virology; 3; 9-2016; 263-281-
dc.identifier2327-056X-
dc.identifierhttp://hdl.handle.net/11336/18191-
dc.identifier2327-0578-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/306198-
dc.descriptionDengue virus affects hundreds of millions of people each year around the world, causing a tremendous social and economic impact on affected countries. The aim of this review is to summarize our current knowledge of the functions, structure, and interactions of the viral capsid protein. The primary role of capsid is to package the viral genome. There are two processes linked to this function: the recruitment of the viral RNA during assembly and the release of the genome during infection. Although particle assembly takes place on endoplasmic reticulum membranes, capsid localizes in nucleoli and lipid droplets. Why capsid accumulates in these locations during infection remains unknown. In this review, we describe available data and discuss new ideas on dengue virus capsid functions and interactions. We believe that a deeper understanding of how the capsid protein works during infection will create opportunities for novel antiviral strategies, which are urgently needed to control dengue virus infections.-
dc.descriptionFil: Byk, Laura Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina-
dc.descriptionFil: Gamarnik, Andrea Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherAnnual Reviews-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.annualreviews.org/doi/10.1146/annurev-virology-110615-042334-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1146/annurev-virology-110615-042334-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectDENGUE-
dc.subjectCAPSID-
dc.subjectVirología-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleProperties and Functions of the Dengue Virus Capsid Protein-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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