Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Sexton, Jane E. | - |
| dc.creator | Desmonds, Terri | - |
| dc.creator | Quick, Kathryn | - |
| dc.creator | Taylor, Ruth | - |
| dc.creator | Abramowitz, Joel | - |
| dc.creator | Forge, Andy | - |
| dc.creator | Kros, Corné J. | - |
| dc.creator | Birnbaumer, Lutz | - |
| dc.creator | Wood, John N. | - |
| dc.date | 2018-06-19T18:03:00Z | - |
| dc.date | 2018-06-19T18:03:00Z | - |
| dc.date | 2016-01 | - |
| dc.date | 2018-06-19T16:52:49Z | - |
| dc.date.accessioned | 2019-04-29T15:57:32Z | - |
| dc.date.available | 2019-04-29T15:57:32Z | - |
| dc.identifier | Sexton, Jane E.; Desmonds, Terri; Quick, Kathryn; Taylor, Ruth; Abramowitz, Joel; et al.; The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing; Elsevier Ireland; Neuroscience Letters; 610; 1-2016; 36-42 | - |
| dc.identifier | 0304-3940 | - |
| dc.identifier | http://hdl.handle.net/11336/49344 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/306236 | - |
| dc.description | Transient receptor potential channels have diverse roles in mechanosensation. Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing. Characteristic features of TRP channels include their high structural homology and their propensity to form heteromeric complexes which suggests potential functional redundancy. We previously showed that TRPC3 and TRPC6 double knockout animals have deficits in light touch and hearing whilst single knockouts were apparently normal. We have extended these studies to analyse deficits in global quadruple TRPC1, 3, 5 and 6 null mutant mice. We examined both touch and hearing in behavioural and electrophysiological assays, and provide evidence that the quadruple knockout mice have larger deficits than the TRPC3 TRPC6 double knockouts. Mechano-electrical transducer currents of cochlear outer hair cells were however normal. This suggests that TRPC1, TRPC3, TRPC5 and TRPC6 channels contribute to cutaneous and auditory mechanosensation in a combinatorial manner, but have no direct role in cochlear mechanotransduction. | - |
| dc.description | Fil: Sexton, Jane E.. University College London; Reino Unido | - |
| dc.description | Fil: Desmonds, Terri. University of Sussex; Reino Unido | - |
| dc.description | Fil: Quick, Kathryn. University College London; Reino Unido | - |
| dc.description | Fil: Taylor, Ruth. University College London; Reino Unido | - |
| dc.description | Fil: Abramowitz, Joel. National Institute of Environmental Health Sciences; Estados Unidos | - |
| dc.description | Fil: Forge, Andy. University College London; Reino Unido | - |
| dc.description | Fil: Kros, Corné J.. University of Sussex; Reino Unido. University of Groningen; Países Bajos | - |
| dc.description | Fil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina. National Institute of Environmental Health Sciences; Estados Unidos | - |
| dc.description | Fil: Wood, John N.. University College London; Reino Unido | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Ireland | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304394015302159 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neulet.2015.10.052 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683096/ | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | MECHANOSENSATION | - |
| dc.subject | TOUCH | - |
| dc.subject | TRP CHANNELS | - |
| dc.subject | DKO | - |
| dc.subject | DOUBLE KNOCKOUT MICE | - |
| dc.subject | QUADKO | - |
| dc.subject | QUADRUPLE KNOCKOUT MICE | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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