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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Comisión de Investigaciones Científicas | - |
| dc.contributor | Fernández, Juan Manuel | - |
| dc.contributor | Molinuevo, Maria Silvina | - |
| dc.contributor | McCarthy, Antonio Desmond | - |
| dc.contributor | Cortizo, Ana María | - |
| dc.creator | Fernández, Juan Manuel | - |
| dc.creator | Molinuevo, Maria Silvina | - |
| dc.creator | McCarthy, Antonio Desmond | - |
| dc.creator | Cortizo, Ana María | - |
| dc.date | 2014 | - |
| dc.date.accessioned | 2019-04-29T16:03:47Z | - |
| dc.date.available | 2019-04-29T16:03:47Z | - |
| dc.date.issued | 2014 | - |
| dc.identifier | http://digital.cic.gba.gob.ar/handle/11746/4725 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/308190 | - |
| dc.description | Strontium ranelate (SR) is an orally administered and bone-targeting anti-osteoporotic agent that increases osteoblast-mediated bone formation while decreasing osteoclastic bone resorption, and thus reduces the risk of vertebral and femoral bone fractures in postmenopausal women with osteoporosis. Osteoblastic alkaline phosphatase (ALP) is a key enzyme involved in the process of bone formation and osteoid mineralization. In this study we investigated the direct effect of strontium (SR and SrCl$latex ^{_{2}} $further decreased Km in all cases. These direct effects of SR on osteoblastic ALP activity could be indicating an alternative mechanism by which this compound may regulate bone matrix mineralization. | - |
| dc.format | application/pdf | - |
| dc.format | 7 p. | - |
| dc.language | eng | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | Attribution 4.0 International (BY 4.0) | - |
| dc.source | reponame:CIC Digital (CICBA) | - |
| dc.source | instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires | - |
| dc.source | instacron:CICBA | - |
| dc.source.uri | http://digital.cic.gba.gob.ar/handle/11746/4725 | - |
| dc.subject | Ciencias Químicas | - |
| dc.title | Strontium ranelate stimulates the activity of bone-specific alkaline phosphatase: interaction with Zn2+ and Mg2+ | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/submittedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | Comisión de Investigaciones Científicas de la Prov. de Buenos Aires | |
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