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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Comisión de Investigaciones Científicas | - |
| dc.contributor | Cortizo, Ana María | - |
| dc.contributor | Caporossi, Mariana | - |
| dc.contributor | Lettieri, Gabriela | - |
| dc.contributor | Etcheverry, Susana B. | - |
| dc.creator | Cortizo, Ana María | - |
| dc.creator | Caporossi, Mariana | - |
| dc.creator | Lettieri, Gabriela | - |
| dc.creator | Etcheverry, Susana B. | - |
| dc.date | 2000 | - |
| dc.date.accessioned | 2019-04-29T16:04:09Z | - |
| dc.date.available | 2019-04-29T16:04:09Z | - |
| dc.date.issued | 2000 | - |
| dc.identifier | http://digital.cic.gba.gob.ar/handle/11746/4448 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/308357 | - |
| dc.description | Nitric oxide NO. has been shown to act as a mediator of cytokines in bone tissue. We have previously demonstrated that vanadium compounds are insulin- and growth factor-mimetic compounds in osteoblasts in culture, although high doses are toxic to these cells. In this study, we measured NO production in two osteoblast-like cells UMR106 and MC3T3E1. incubated with different concentrations 2.5–100 mM. of vanadate. Vanadate induced NO release in a biphasic manner, with levels being significantly increased at concentrations over 50 mM. The NO donor, sodium nitroprusside, mimicked the vanadate effect: it inhibited cell growth and alkaline phosphatase activity in a dose-dependent manner. Vanadate enhanced the NO synthases, the endothelial and inducible eNOS and iNOS. isoforms, in a dose-dependent manner. Experiments performed with the ionophore A23187 and EGTA suggested that vanadate-induced NO production involves Ca2q-dependent and -independent mechanisms. Altogether, our results suggest that NO may play a critical role in the bioactivity of vanadium in osteoblast-like cells. q2000 Elsevier Science B.V. All rights reserved. | - |
| dc.format | application/pdf | - |
| dc.format | 7 p. | - |
| dc.language | spa | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | Attribution 4.0 International (BY 4.0) | - |
| dc.source | reponame:CIC Digital (CICBA) | - |
| dc.source | instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires | - |
| dc.source | instacron:CICBA | - |
| dc.source.uri | http://digital.cic.gba.gob.ar/handle/11746/4448 | - |
| dc.subject | Ciencias Químicas | - |
| dc.title | Vanadate-induced nitric oxide production: role in osteoblast growth and differentiation | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/submittedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | Comisión de Investigaciones Científicas de la Prov. de Buenos Aires | |
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