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dc.provenanceComisión de Investigaciones Científicas-
dc.contributorMcCarthy, Antonio Desmond-
dc.contributorEtcheverry, Susana B.-
dc.contributorBruzzone, Liliana-
dc.contributorCortizo, Ana María-
dc.creatorMcCarthy, Antonio Desmond-
dc.creatorEtcheverry, Susana B.-
dc.creatorBruzzone, Liliana-
dc.creatorCortizo, Ana María-
dc.date1997-
dc.date.accessioned2019-04-29T16:06:24Z-
dc.date.available2019-04-29T16:06:24Z-
dc.date.issued1997-
dc.identifierhttp://digital.cic.gba.gob.ar/handle/11746/4899-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/309330-
dc.descriptionTwo different lines of osteoblast-like cells were used to investigate the effect of advanced glycation end-products of bovine serum albumin on cell proliferation and differentiation. These parameters were found to be both dose- and time-dependent. Cell proliferation remained unchanged after a 24 h incubation period, it increased after intermediate periods of incubation with advanced glycation end-products, but was found to be depressed after several days incubation. Cellular alkaline phosphatase activity followed a similar pattern: an initial increase induced by advanced glycation end-products was generally followed, after relatively long incubation periods, by a slight but significant decrease in this parameter. 45Ca2+ uptake was only significantly inhibited by advanced glycation end-products after 24 h incubation. These results suggest that advanced glycation end-products directly regulate osteoblast proliferation and differentiation in a dose and time dependent manner.-
dc.formatapplication/pdf-
dc.format9 p.-
dc.languagespa-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightsAttribution 4.0 International (BY 4.0)-
dc.sourcereponame:CIC Digital (CICBA)-
dc.sourceinstname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires-
dc.sourceinstacron:CICBA-
dc.source.urihttp://digital.cic.gba.gob.ar/handle/11746/4899-
dc.subjectCiencias Químicas-
dc.titleEffects of advanced glycation end-products on the proliferation and differentiation of osteoblast-like cells-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/submittedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
Aparece en las colecciones: Comisión de Investigaciones Científicas de la Prov. de Buenos Aires

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