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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Comisión de Investigaciones Científicas | - |
| dc.contributor | Castrogiovanni, Daniel | - |
| dc.contributor | Alzamendi, Ana | - |
| dc.contributor | Ongaro, Luisina | - |
| dc.contributor | Giovambattista, Andrés | - |
| dc.contributor | Gaillard, Rolf | - |
| dc.contributor | Spinedi, Eduardo | - |
| dc.creator | Castrogiovanni, Daniel | - |
| dc.creator | Alzamendi, Ana | - |
| dc.creator | Ongaro, Luisina | - |
| dc.creator | Giovambattista, Andrés | - |
| dc.creator | Gaillard, Rolf | - |
| dc.creator | Spinedi, Eduardo | - |
| dc.date | 2012-08 | - |
| dc.date.accessioned | 2019-04-29T16:08:36Z | - |
| dc.date.available | 2019-04-29T16:08:36Z | - |
| dc.date.issued | 2012-08 | - |
| dc.identifier | http://digital.cic.gba.gob.ar/handle/11746/7036 | - |
| dc.identifier | Recurso online | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/310211 | - |
| dc.description | The effect of progesterone (P4) on fructose rich diet (FRD) intake-induced metabolic, endocrine and parametrial adipose tissue (PMAT) dysfunctions was studied in the adult female rat. Sixty day-old rats were i.m. treated with oil alone (control, CT) or containing P4 (12 mg/kg). Rats ate Purina chow-diet ad libitum throughout the entire experiment and, between 100 and 120 days of age drank ad libitum tap water alone (normal diet; CT-ND and P4-ND) or containing fructose (10% w/v; CT-FRD and P4-FRD). At age 120 days, animals were subjected to a glucose tolerance test or decapitated. Plasma concentrations of various biomarkers and PMAT gene abundance were monitored. P4-ND (vs. CT-ND) rats showed elevated circulating levels of lipids. CT-FRD rats displayed high (vs. CT-ND) plasma concentrations of lipids, leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1). Lipidemia and adiponectinemia were high (vs. P4-ND) in P4-FRD rats. Although P4 failed to prevent FRD-induced hyperleptinemia, it was fully protective on FRD-enhanced plasma PAI-1 levels. PMAT leptin and adiponectin mRNAs were high in CT-FRD and P4-FRD rats. While FRD enhanced PMAT PAI-1 mRNA abundance in CT rats, this effect was absent in P4 rats. Our study supports that a preceding P4-enriched milieu prevented the enhanced prothrombotic risk induced by FRD-elicited high PAI-1 production. | - |
| dc.format | application/pdf | - |
| dc.format | 14 p. | - |
| dc.language | eng | - |
| dc.publisher | MDPI (Multidisciplinary Digital Publishing Institute) | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | Attribution 4.0 International (BY 4.0) | - |
| dc.source | reponame:CIC Digital (CICBA) | - |
| dc.source | instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires | - |
| dc.source | instacron:CICBA | - |
| dc.source.uri | http://digital.cic.gba.gob.ar/handle/11746/7036 | - |
| dc.source.uri | Recurso online | - |
| dc.subject | Biología Celular, Microbiología | - |
| dc.title | Fructose Rich Diet-Induced High Plasminogen Activator Inhibitor-1 (PAI-1) Production in the Adult Female Rat: Protective Effect of Progesterone | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | Comisión de Investigaciones Científicas de la Prov. de Buenos Aires | |
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