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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Comisión de Investigaciones Científicas | - |
| dc.contributor | Zubiría, Guillermina | - |
| dc.contributor | Alzamendi, Ana | - |
| dc.contributor | Moreno, Griselda | - |
| dc.contributor | Rey, María Amanda | - |
| dc.contributor | Spinedi, Eduardo | - |
| dc.contributor | Giovambattista, Andrés | - |
| dc.creator | Zubiría, Guillermina | - |
| dc.creator | Alzamendi, Ana | - |
| dc.creator | Moreno, Griselda | - |
| dc.creator | Rey, María Amanda | - |
| dc.creator | Spinedi, Eduardo | - |
| dc.creator | Giovambattista, Andrés | - |
| dc.date | 2016-04 | - |
| dc.date.accessioned | 2019-04-29T16:08:44Z | - |
| dc.date.available | 2019-04-29T16:08:44Z | - |
| dc.date.issued | 2016-04 | - |
| dc.identifier | http://digital.cic.gba.gob.ar/handle/11746/7020 | - |
| dc.identifier | Recurso online | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/310257 | - |
| dc.description | We have previously addressed that fructose rich diet (FRD) intake for three weeks increases the adipogenic potential of stromal vascular fraction cells from the retroperitoneal adipose tissue (RPAT). We have now evaluated the effect of prolonged FRD intake (eight weeks) on metabolic parameters, number of adipocyte precursor cells (APCs) and in vitro adipogenic potential from control (CTR) and FRD adult male rats. Additionally, we have examined the direct fructose effects on the adipogenic capacity of normal APCs. FRD fed rats had increased plasma levels of insulin, triglyceride and leptin, and RPAT mass and adipocyte size. FACS studies showed higher APCs number and adipogenic potential in FRD RPAT pads; data is supported by high mRNA levels of competency markers: PPARγ2 and Zfp423. Complementary in vitro experiments indicate that fructose-exposed normal APCs displayed an overall increased adipogenic capacity. We conclude that the RPAT mass expansion observed in eight week-FRD fed rats depends on combined accelerated adipogenesis and adipocyte hypertrophy, partially due to a direct effect of fructose on APCs. | - |
| dc.format | application/pdf | - |
| dc.format | 15 p. | - |
| dc.language | eng | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | Attribution 4.0 International (BY 4.0) | - |
| dc.source | reponame:CIC Digital (CICBA) | - |
| dc.source | instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires | - |
| dc.source | instacron:CICBA | - |
| dc.source.uri | http://digital.cic.gba.gob.ar/handle/11746/7020 | - |
| dc.source.uri | Recurso online | - |
| dc.subject | Biología Celular, Microbiología | - |
| dc.title | Long-Term Fructose Intake Increases Adipogenic Potential: Evidence of Direct Effects of Fructose on Adipocyte Precursor Cells | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | Comisión de Investigaciones Científicas de la Prov. de Buenos Aires | |
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