Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Comisión de Investigaciones Científicas | - |
| dc.contributor | Garg, Rachana | - |
| dc.contributor | Benedetti, Lorena G. | - |
| dc.contributor | Abera, Mahlet B. | - |
| dc.contributor | Wang, HongBin | - |
| dc.contributor | Abba, Martín Carlos | - |
| dc.contributor | Kazanietz, Marcelo G. | - |
| dc.creator | Garg, Rachana | - |
| dc.creator | Benedetti, Lorena G. | - |
| dc.creator | Abera, Mahlet B. | - |
| dc.creator | Wang, HongBin | - |
| dc.creator | Abba, Martín Carlos | - |
| dc.creator | Kazanietz, Marcelo G. | - |
| dc.date | 2014-11 | - |
| dc.date.accessioned | 2019-04-29T16:09:08Z | - |
| dc.date.available | 2019-04-29T16:09:08Z | - |
| dc.date.issued | 2014-11 | - |
| dc.identifier | http://digital.cic.gba.gob.ar/handle/11746/6197 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/310385 | - |
| dc.description | Since their discovery in the late 1970’s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment. | - |
| dc.format | application/pdf | - |
| dc.format | 34 p. | - |
| dc.language | eng | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | Attribution-NonCommercial 4.0 International (BY-NC 4.0) | - |
| dc.source | reponame:CIC Digital (CICBA) | - |
| dc.source | instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires | - |
| dc.source | instacron:CICBA | - |
| dc.source.uri | http://digital.cic.gba.gob.ar/handle/11746/6197 | - |
| dc.subject | Ciencias Médicas | - |
| dc.title | Protein kinase C and cancer: what we know and what we do not | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/submittedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | Comisión de Investigaciones Científicas de la Prov. de Buenos Aires | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.