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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Comisión de Investigaciones Científicas | - |
| dc.contributor | Alzamendi, Ana | - |
| dc.contributor | Giovambattista, Andrés | - |
| dc.contributor | Garcia, María Elisa | - |
| dc.contributor | Rebolledo, Oscar R. | - |
| dc.contributor | Gagliardino, Juan José | - |
| dc.contributor | Spinedi, Eduardo | - |
| dc.creator | Alzamendi, Ana | - |
| dc.creator | Giovambattista, Andrés | - |
| dc.creator | Garcia, María Elisa | - |
| dc.creator | Rebolledo, Oscar R. | - |
| dc.creator | Gagliardino, Juan José | - |
| dc.creator | Spinedi, Eduardo | - |
| dc.date | 2012 | - |
| dc.date.accessioned | 2019-04-29T16:10:58Z | - |
| dc.date.available | 2019-04-29T16:10:58Z | - |
| dc.date.issued | 2012 | - |
| dc.identifier | http://digital.cic.gba.gob.ar/handle/11746/7076 | - |
| dc.identifier | Recurso online | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/311119 | - |
| dc.description | Aim. To test the potential role of PPARγ in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology. Adult normal male rats received a standard commercial diet (CD) or FRD, (10% in drinking water) without or with pioglitazone (PIO) (i.p. 0.25mg/Kg BW/day; CD-PIO and FRD-PIO). Thereafter, we measured circulating metabolic, endocrine, and oxidative stress (OS) markers, abdominal adipose tissue (AAT) mass, leptin (LEP) and plasminogen activator inhibitor-1 (PAI-1) tissue content/expression, and leptin release by isolated adipocytes incubated with different concentrations of insulin. Results. Plasma glucose, insulin, triglyceride, TBARS, LEP, and PAI-1 levels were higher in FRD rats; PIO coadministration fully prevented all these increments. AAT adipocytes from FRD rats were larger, secreted a higher amount of LEP, and displayed decreased sensitivity to insulin stimulation; these effects were significantly ameliorated by PIO. Whereas AAT LEP and PAI-1 (mRNA) concentrations increased significantly in FRD rats, those of insulin-receptor-substrate- (IRS-) 1 and IRS-2 were reduced. PIO coadministration prevented FRD effects on LEP, PAI-1, and IRS-2 (fully) and IRS-1 (partially) mRNAs in AAT. Conclusion. PPARγ would play a relevant role in the development of the FRD-induced metabolicendocrine dysfunction. | - |
| dc.format | application/pdf | - |
| dc.format | 10 p. | - |
| dc.language | eng | - |
| dc.publisher | Hindawi Publishing Corporation | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | Attribution 4.0 International (BY 4.0) | - |
| dc.source | reponame:CIC Digital (CICBA) | - |
| dc.source | instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires | - |
| dc.source | instacron:CICBA | - |
| dc.source.uri | http://digital.cic.gba.gob.ar/handle/11746/7076 | - |
| dc.source.uri | Recurso online | - |
| dc.subject | Biología Celular, Microbiología | - |
| dc.title | Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | Comisión de Investigaciones Científicas de la Prov. de Buenos Aires | |
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