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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Comisión de Investigaciones Científicas | - |
| dc.contributor | Cortizo, Ana María | - |
| dc.contributor | Sedlinsky, Claudia | - |
| dc.contributor | McCarthy, Antonio Desmond | - |
| dc.contributor | Blanco, Alcira | - |
| dc.contributor | Schurman, León | - |
| dc.creator | Cortizo, Ana María | - |
| dc.creator | Sedlinsky, Claudia | - |
| dc.creator | McCarthy, Antonio Desmond | - |
| dc.creator | Blanco, Alcira | - |
| dc.creator | Schurman, León | - |
| dc.date | 2006 | - |
| dc.date.accessioned | 2019-04-29T16:13:03Z | - |
| dc.date.available | 2019-04-29T16:13:03Z | - |
| dc.date.issued | 2006 | - |
| dc.identifier | http://digital.cic.gba.gob.ar/handle/11746/4418 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/311817 | - |
| dc.description | An association has been previously established between uncompensated diabetes mellitus and the loss of bone mineral density and/or quality. In this study, we evaluated the effects of metformin on the growth and differentiation of osteoblasts in culture. Treatment of two osteoblast-like cells (UMR106 and MC3T3E1) with metformin (25–500μM) for 24h led to a dose-dependent increase of cell proliferation. Metformin also promoted osteoblastic differentiation: it increased type-I collagen production in both cell lines and stimulated alkaline phosphatase activity in MC3T3E1 osteoblasts. In addition, metformin markedly increased the formation of nodules of mineralization in 3-week MC3T3E1 cultures. Metformin induced activation and redistribution of phosphorylated extracellular signal-regulated kinase (P-ERK) in a transient manner, and dosedependently stimulated the expression of endothelial and inducible nitric oxide synthases (e/iNOS). These results show for the first time a direct osteogenic effect of metformin on osteoblasts in culture, which could be mediated by activation/redistribution of ERK-1/2 and induction of e/ iNOS. | - |
| dc.format | application/pdf | - |
| dc.format | 9 p. | - |
| dc.language | eng | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | Attribution 4.0 International (BY 4.0) | - |
| dc.source | reponame:CIC Digital (CICBA) | - |
| dc.source | instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires | - |
| dc.source | instacron:CICBA | - |
| dc.source.uri | http://digital.cic.gba.gob.ar/handle/11746/4418 | - |
| dc.subject | Ciencias Químicas | - |
| dc.title | Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/submittedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | Comisión de Investigaciones Científicas de la Prov. de Buenos Aires | |
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