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dc.provenanceINTA-
dc.contributorDemars, Julie-
dc.contributorCano, Ema Margarita-
dc.contributorDrouilhet, Laurence-
dc.contributorPlisson-Petit, Florence-
dc.contributorBardou, Philippe-
dc.contributorFabre, Stéphane-
dc.contributorServin, Bertrand-
dc.contributorSarry, Julien-
dc.contributorWoloszyn, Florent-
dc.contributorMulsant, Philippe-
dc.contributorFoulquier, Didier-
dc.contributorCarriere, Fabien-
dc.contributorAletru, Mathias-
dc.contributorRodde, Nathalie-
dc.contributorCauet, Stéphane-
dc.contributorBouchez, Olivier-
dc.contributorPirson, Maarten-
dc.contributorTosser-Klopp, Gwenola-
dc.contributorAllain, Daniel-
dc.creatorDemars, Julie-
dc.creatorCano, Ema Margarita-
dc.creatorDrouilhet, Laurence-
dc.creatorPlisson-Petit, Florence-
dc.creatorBardou, Philippe-
dc.creatorFabre, Stéphane-
dc.creatorServin, Bertrand-
dc.creatorSarry, Julien-
dc.creatorWoloszyn, Florent-
dc.creatorMulsant, Philippe-
dc.creatorFoulquier, Didier-
dc.creatorCarriere, Fabien-
dc.creatorAletru, Mathias-
dc.creatorRodde, Nathalie-
dc.creatorCauet, Stéphane-
dc.creatorBouchez, Olivier-
dc.creatorPirson, Maarten-
dc.creatorTosser-Klopp, Gwenola-
dc.creatorAllain, Daniel-
dc.date2017-08-22T17:11:50Z-
dc.date2017-08-22T17:11:50Z-
dc.date2017-07-
dc.date.accessioned2019-04-29T16:26:28Z-
dc.date.available2019-04-29T16:26:28Z-
dc.date.issued2017-08-22T17:11:50Z-
dc.date.issued2017-08-22T17:11:50Z-
dc.date.issued2017-07-
dc.identifier1537-1719-
dc.identifierhttps://doi.org/10.1093/molbev/msx114-
dc.identifierhttp://hdl.handle.net/20.500.12123/1007-
dc.identifierhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455980/-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/313289-
dc.descriptionThe composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation.-
dc.descriptionInstituto de Genética-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherOxford university press-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.sourceMolecular Biology and Evolution 34 (7) : 1722-1729 (July 2017)-
dc.sourcereponame:INTA Digital (INTA)-
dc.sourceinstname:Instituto Nacional de Tecnología Agropecuaria-
dc.sourceinstacron:INTA-
dc.source.uri1537-1719-
dc.source.urihttps://doi.org/10.1093/molbev/msx114-
dc.source.urihttp://hdl.handle.net/20.500.12123/1007-
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455980/-
dc.source.urihttps://doi.org/10.1093/molbev/msx114-
dc.source.urihttp://hdl.handle.net/20.500.12123/1007-
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455980/-
dc.subjectGenética-
dc.subjectOvinos-
dc.subjectMutación-
dc.subjectGenetics-
dc.subjectSheep-
dc.subjectMutation-
dc.titleGenome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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