Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | INTA | - |
| dc.contributor | Bigi, María Mercedes | - |
| dc.contributor | Blanco, Federico Carlos | - |
| dc.contributor | Araujo, Flabio R. | - |
| dc.contributor | Thacker, Tyler C. | - |
| dc.contributor | Zumarraga, Martin Jose | - |
| dc.contributor | Cataldi, Angel Adrian | - |
| dc.contributor | Soria, Marcelo Abel | - |
| dc.contributor | Bigi, Fabiana | - |
| dc.creator | Bigi, María Mercedes | - |
| dc.creator | Blanco, Federico Carlos | - |
| dc.creator | Araujo, Flabio R. | - |
| dc.creator | Thacker, Tyler C. | - |
| dc.creator | Zumarraga, Martin Jose | - |
| dc.creator | Cataldi, Angel Adrian | - |
| dc.creator | Soria, Marcelo Abel | - |
| dc.creator | Bigi, Fabiana | - |
| dc.date | 2017-09-11T12:26:47Z | - |
| dc.date | 2017-09-11T12:26:47Z | - |
| dc.date | 2016 | - |
| dc.date.accessioned | 2019-04-29T16:26:57Z | - |
| dc.date.available | 2019-04-29T16:26:57Z | - |
| dc.date.issued | 2017-09-11T12:26:47Z | - |
| dc.date.issued | 2017-09-11T12:26:47Z | - |
| dc.date.issued | 2016 | - |
| dc.identifier | 0385-5600 (Print) | - |
| dc.identifier | 1348-0421 (Online) | - |
| dc.identifier | DOI: 10.1111/1348-0421.12402 | - |
| dc.identifier | http://hdl.handle.net/20.500.12123/1186 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/313455 | - |
| dc.description | Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis | - |
| dc.description | Inst. de Biotecnología | - |
| dc.description | Fil: Bigi, María Mercedes. Universidad de Buenos Aires; Argentina | - |
| dc.description | Fil: Blanco, Federico Carlos. INTA. Instituto de Biotecnología; Argentina | - |
| dc.description | Fil: Araujo, Flabio R. EMBRAPA Mato Grosso do Sul; Brasil | - |
| dc.description | Fil: Thacker, Tyler C. United States Department of Agriculture. Agricultural Research Service. National Animal Disease Center; Estados Unidos | - |
| dc.description | Fil: Zumarraga, Martin Jose. INTA. Instituto de Biotecnología; Argentina | - |
| dc.description | Fil: Cataldi, Angel Adrian. INTA. Instituto de Biotecnología; Argentina | - |
| dc.description | Fil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Biología Aplicada y Alimentos. Cátedra de Microbiología Agrícola; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales; Argentina | - |
| dc.description | Fil: Bigi, Fabiana. INTA. Instituto de Biotecnología; Argentina | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.source | Microbiology and Immunology 60 (8) : 552–560 (August 2016) | - |
| dc.source | reponame:INTA Digital (INTA) | - |
| dc.source | instname:Instituto Nacional de Tecnología Agropecuaria | - |
| dc.source | instacron:INTA | - |
| dc.source.uri | 0385-5600 (Print) | - |
| dc.source.uri | 1348-0421 (Online) | - |
| dc.source.uri | DOI: 10.1111/1348-0421.12402 | - |
| dc.source.uri | http://hdl.handle.net/20.500.12123/1186 | - |
| dc.source.uri | http://hdl.handle.net/20.500.12123/1186 | - |
| dc.subject | Enfermedades de los Animales | - |
| dc.subject | Mycobacterium Tuberculosis | - |
| dc.subject | Mycobacterium Bovis | - |
| dc.subject | Enfermedades Infecciosas | - |
| dc.subject | Polimorfismo | - |
| dc.subject | Animal Diseases | - |
| dc.subject | Infectious Diseases | - |
| dc.subject | Polymorphism | - |
| dc.title | Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/acceptedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | INTA | |
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