1. RODNA
  2. INTA
  3. INTA
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.provenanceINTA-
dc.contributorTavarone, Maria Eugenia-
dc.contributorMolina, Guido Nicolas-
dc.contributorAmalfi, Sabrina-
dc.contributorPeralta, Andrea Veronica-
dc.contributorMolinari, Maria Paula-
dc.contributorTaboga, Oscar Alberto-
dc.contributorDiaz, Silvio Ricardo-
dc.contributorGravisaco, Marí­a José-
dc.creatorTavarone, Maria Eugenia-
dc.creatorMolina, Guido Nicolas-
dc.creatorAmalfi, Sabrina-
dc.creatorPeralta, Andrea Veronica-
dc.creatorMolinari, Maria Paula-
dc.creatorTaboga, Oscar Alberto-
dc.creatorDiaz, Silvio Ricardo-
dc.creatorGravisaco, Marí­a José-
dc.date2017-09-28T14:04:52Z-
dc.date2017-09-28T14:04:52Z-
dc.date2017-05-
dc.date.accessioned2019-04-29T16:27:22Z-
dc.date.available2019-04-29T16:27:22Z-
dc.date.issued2017-09-28T14:04:52Z-
dc.date.issued2017-09-28T14:04:52Z-
dc.date.issued2017-05-
dc.identifier0175-7598 (Print)-
dc.identifier1432-0614 (Online)-
dc.identifierhttps://doi.org/10.1007/s00253-017-8183-y-
dc.identifierhttp://hdl.handle.net/20.500.12123/1348-
dc.identifierhttps://link.springer.com/article/10.1007%2Fs00253-017-8183-y-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/313599-
dc.descriptionIn the search of strategies of presentation of heterologous antigens to elicit humoral or cellular immune responses that modulate and properly potentiate each type of response, researchers have been studying baculovirus (BV) as vaccine vectors with promising results. For some years, several research groups explored different antigen presentation approaches using the BV AcNPV by expressing polypeptides on the surface of budded virions or by de novo synthesis of heterologous antigens by transduction of mammalian cells. In the case of expression on the surface of budded virions, for example, researchers have expressed polypeptides in peplomers as GP64 glycoprotein fusions or distributed throughout the entire surface by fusions to portions of the G protein of vesicular stomatitis virus, VSV. Recently, our group developed the strategy of crosspresentation of antigens by fusions ofGP64 to the capsid protein VP39 (capsid display) for the generation of cytotoxic responses. While the different strategies showed to be effective in raising immune responses, the individuality of each analysis makes difficult the comparison of the results. Here, by comparing the different strategies, we show that localization of the model antigen ovalbumin (OVA) strongly determined the quality and intensity of the adaptive response to the heterologous antigen. Furthermore, surface display favored humoral responses,whereas capsid display favored cytotoxic responses. Finally, capsid display showed a much more efficient strategy to activate CD8-mediated responses than transduction. The incorporation of adjuvants in baculovirus formulations dramatically diminished the immunostimulatory properties of baculovirus.-
dc.descriptionInst. de Biotecnología-
dc.descriptionFil: Tavarone, Maria Eugenia. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Molina, Guido Nicolas. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Amalfi, Sabrina. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Peralta, Andrea Veronica. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Molinari, Maria Paula. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Taboga, Oscar Alberto. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Diaz, Silvio Ricardo. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Gravisaco, Marí­a José. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.formatapplication/pdf-
dc.languageeng-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.sourceApplied Microbiology and Biotechnology 101 (10) : 4175–4184 (May 2017)-
dc.sourcereponame:INTA Digital (INTA)-
dc.sourceinstname:Instituto Nacional de Tecnología Agropecuaria-
dc.sourceinstacron:INTA-
dc.source.uri0175-7598 (Print)-
dc.source.uri1432-0614 (Online)-
dc.source.urihttps://doi.org/10.1007/s00253-017-8183-y-
dc.source.urihttp://hdl.handle.net/20.500.12123/1348-
dc.source.urihttps://link.springer.com/article/10.1007%2Fs00253-017-8183-y-
dc.source.urihttps://doi.org/10.1007/s00253-017-8183-y-
dc.source.urihttp://hdl.handle.net/20.500.12123/1348-
dc.source.urihttps://link.springer.com/article/10.1007%2Fs00253-017-8183-y-
dc.subjectImmunization-
dc.subjectImmune Response-
dc.subjectAntigens-
dc.subjectGenetics-
dc.subjectInmunización-
dc.subjectRespuesta Inmunológica-
dc.subjectBaculovirus-
dc.subjectAntígenos-
dc.titleThe localization of a heterologous displayed antigen in the baculovirus-budded virion determines the type and strength of induced adaptive immune response-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
Aparece en las colecciones: INTA

Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro sencillo del ítem