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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | INTA | - |
| dc.contributor | Mansilla, Florencia Celeste | - |
| dc.contributor | Quintana, Maria Eugenia | - |
| dc.contributor | Cardoso, Nancy | - |
| dc.contributor | Capozzo, Alejandra | - |
| dc.creator | Mansilla, Florencia Celeste | - |
| dc.creator | Quintana, Maria Eugenia | - |
| dc.creator | Cardoso, Nancy | - |
| dc.creator | Capozzo, Alejandra | - |
| dc.date | 2017-09-29T15:19:32Z | - |
| dc.date | 2017-09-29T15:19:32Z | - |
| dc.date | 2016 | - |
| dc.date.accessioned | 2019-04-29T16:27:25Z | - |
| dc.date.available | 2019-04-29T16:27:25Z | - |
| dc.date.issued | 2017-09-29T15:19:32Z | - |
| dc.date.issued | 2017-09-29T15:19:32Z | - |
| dc.date.issued | 2016 | - |
| dc.identifier | 0141-9838 (Print) | - |
| dc.identifier | 1365-3024 (Online) | - |
| dc.identifier | DOI: 10.1111/pim.12354 | - |
| dc.identifier | http://hdl.handle.net/20.500.12123/1363 | - |
| dc.identifier | http://onlinelibrary.wiley.com/doi/10.1111/pim.12354/abstract;jsessionid=FACB86FBF3713A6913E5AF348898AEE4.f03t02?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+7th+Oct+from+03.00+EDT+%2F+08%3A00+BST+%2F+12%3A30+IST+%2F+15.00+SGT+to+08.00+EDT+%2F+13.00+BST+%2F+17%3A30+IST+%2F+20.00+SGT+and+Sunday+8th+Oct+from+03.00+EDT+%2F+08%3A00+BST+%2F+12%3A30+IST+%2F+15.00+SGT+to+06.00+EDT+%2F+11.00+BST+%2F+15%3A30+IST+%2F+18.00+SGT+for+essential+maintenance.+Apologies+for+the+inconvenience+caused+.# | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/313612 | - |
| dc.description | We demonstrated recently that immunization with recombinant Neospora caninum profilin (rNcPRO) induces limited protection and a regulatory T-cell response in mice. The aim of this study was to evaluate the immune response elicited by rNcPRO in cattle and assess a strategy to enhance its immunogenicity, combining the addition of T-cell epitopes and immune modulators. We developed a chimeric recombinant profilin fused to functional T-cell epitopes present in the N terminal sequence of vesicular stomatitis virus (VSV) glycoprotein G (rNcPRO/G). Groups of three cattle were immunized with two doses (2 weeks apart) of rNcPRO or rNcPRO/G formulated with alum hydroxide or a nanoparticulated soya-based adjuvant enriched with Toll-like receptor (TLR) 2 and TLR9 agonists, aimed to tackle the MyD88 pathway (AVECplus). rNcPRO induced only a primary immune response (IgM mediated), while antibodies in rNcPRO/G-vaccinated animals switched to IgG1 after the booster. The vaccine formulated with rNcPRO/G and AVECplus improved the production of systemic IFN-γ and induced long-term recall B-cell responses. Overall, our study provides data supporting the use of T-cell epitopes from VSV glycoprotein G and TLR agonists to enhance and modulate immunity to peptide antigens in bovines, particularly when using small proteins from parasites for which immune responses are usually feeble. | - |
| dc.description | Inst.de Virología | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.source | Parasite Immunology 38 (11) : 663–669 (November 2016) | - |
| dc.source | reponame:INTA Digital (INTA) | - |
| dc.source | instname:Instituto Nacional de Tecnología Agropecuaria | - |
| dc.source | instacron:INTA | - |
| dc.source.uri | 0141-9838 (Print) | - |
| dc.source.uri | 1365-3024 (Online) | - |
| dc.source.uri | DOI: 10.1111/pim.12354 | - |
| dc.source.uri | http://hdl.handle.net/20.500.12123/1363 | - |
| dc.source.uri | http://onlinelibrary.wiley.com/doi/10.1111/pim.12354/abstract;jsessionid=FACB86FBF3713A6913E5AF348898AEE4.f03t02?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+7th+Oct+from+03.00+EDT+%2F+08%3A00+BST+%2F+12%3A30+IST+%2F+15.00+SGT+to+08.00+EDT+%2F+13.00+BST+%2F+17%3A30+IST+%2F+20.00+SGT+and+Sunday+8th+Oct+from+03.00+EDT+%2F+08%3A00+BST+%2F+12%3A30+IST+%2F+15.00+SGT+to+06.00+EDT+%2F+11.00+BST+%2F+15%3A30+IST+%2F+18.00+SGT+for+essential+maintenance.+Apologies+for+the+inconvenience+caused+.# | - |
| dc.source.uri | http://hdl.handle.net/20.500.12123/1363 | - |
| dc.source.uri | http://onlinelibrary.wiley.com/doi/10.1111/pim.12354/abstract;jsessionid=FACB86FBF3713A6913E5AF348898AEE4.f03t02?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+7th+Oct+from+03.00+EDT+%2F+08%3A00+BST+%2F+12%3A30+IST+%2F+15.00+SGT+to+08.00+EDT+%2F+13.00+BST+%2F+17%3A30+IST+%2F+20.00+SGT+and+Sunday+8th+Oct+from+03.00+EDT+%2F+08%3A00+BST+%2F+12%3A30+IST+%2F+15.00+SGT+to+06.00+EDT+%2F+11.00+BST+%2F+15%3A30+IST+%2F+18.00+SGT+for+essential+maintenance.+Apologies+for+the+inconvenience+caused+.# | - |
| dc.subject | Genetics | - |
| dc.subject | Cattle | - |
| dc.subject | T-lymphocytes | - |
| dc.subject | Immunity | - |
| dc.subject | Genética | - |
| dc.subject | Ganado Bovino | - |
| dc.subject | Neospora Caninum | - |
| dc.subject | Linfocitos-t | - |
| dc.subject | Inmunidad | - |
| dc.title | Fusion of foreign T-cell epitopes and addition of TLR agonists enhance immunity against Neospora caninum profilin in cattle | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/acceptedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | INTA | |
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