1. RODNA
  2. INTA
  3. INTA
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.provenanceINTA-
dc.contributorCacciabue, Marco Polo-
dc.contributorGarcia Nuñez, Maria Soledad-
dc.contributorDelgado, Fernando Oscar-
dc.contributorCurra, Anabella Paola-
dc.contributorMarrero Diaz De Villegas, Rubén-
dc.contributorMolinari, Maria Paula-
dc.contributorRieder, Elizabeth-
dc.contributorCarrillo, Elisa Cristina-
dc.contributorGismondi, Maria Ines-
dc.creatorCacciabue, Marco Polo-
dc.creatorGarcia Nuñez, Maria Soledad-
dc.creatorDelgado, Fernando Oscar-
dc.creatorCurra, Anabella Paola-
dc.creatorMarrero Diaz De Villegas, Rubén-
dc.creatorMolinari, Maria Paula-
dc.creatorRieder, Elizabeth-
dc.creatorCarrillo, Elisa Cristina-
dc.creatorGismondi, Maria Ines-
dc.date2017-10-11T15:27:35Z-
dc.date2017-10-11T15:27:35Z-
dc.date2017-09-
dc.date.accessioned2019-04-29T16:27:41Z-
dc.date.available2019-04-29T16:27:41Z-
dc.date.issued2017-10-11T15:27:35Z-
dc.date.issued2017-10-11T15:27:35Z-
dc.date.issued2017-09-
dc.identifier0042-6822-
dc.identifierhttps://doi.org/10.1016/j.virol.2017.06.012-
dc.identifierhttp://hdl.handle.net/20.500.12123/1464-
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0042682217301903-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/313699-
dc.descriptionAdult C57BL/6J mice have been used to study Foot-and-mouth disease virus (FMDV) biology. In this work, two variants of an FMDV A/Arg/01 strain exhibiting differential pathogenicity in adult mice were identified and characterized: a non-lethal virus (A01NL) caused mild signs of disease, whereas a lethal virus (A01L) caused death within 24–48 h independently of the dose used. Both viruses caused a systemic infection with pathological changes in the exocrine pancreas. Virus A01L reached higher viral loads in plasma and organs of inoculated mice as well as increased replication in an ovine kidney cell line. Complete consensus sequences revealed 6 nonsynonymous changes between A01L and A10NL genomes that might be linked to replication differences, as suggested by in silico prediction studies. Our results highlight the biological significance of discrete genomic variations and reinforce the usefulness of this animal model to study viral determinants of lethality.-
dc.descriptionInst. de Biotecnología-
dc.descriptionFil: Cacciabue, Marco Polo. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Garcia Nuñez, Maria Soledad. INTA. Instituto de Biotecnología; Argentina-
dc.descriptionFil: Delgado, Fernando Oscar. INTA. Instituto de Patobiología; Argentina-
dc.descriptionFil: Curra, Anabella Paola. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Marrero Diaz De Villegas, Rubén. INTA. Instituto de Biotecnología; Argentina-
dc.descriptionFil: Molinari, Maria Paula. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Carrillo, Elisa Cristina. INTA. Centro de Investigación en Ciencias Veterinarias y Agronómicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Gismondi, Maria Ines. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.formatapplication/pdf-
dc.languageeng-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.sourceVirology 509 : 195-204 (September 2017)-
dc.sourcereponame:INTA Digital (INTA)-
dc.sourceinstname:Instituto Nacional de Tecnología Agropecuaria-
dc.sourceinstacron:INTA-
dc.source.uri0042-6822-
dc.source.urihttps://doi.org/10.1016/j.virol.2017.06.012-
dc.source.urihttp://hdl.handle.net/20.500.12123/1464-
dc.source.urihttp://www.sciencedirect.com/science/article/pii/S0042682217301903-
dc.source.urihttps://doi.org/10.1016/j.virol.2017.06.012-
dc.source.urihttp://hdl.handle.net/20.500.12123/1464-
dc.source.urihttp://www.sciencedirect.com/science/article/pii/S0042682217301903-
dc.subjectRatón-
dc.subjectFiebre Aftosa-
dc.subjectPatogénesis-
dc.subjectMice-
dc.subjectFoot and Mouth Disease-
dc.subjectPathogenesis-
dc.titleDifferential replication of Foot-and-mouth disease viruses in mice determine lethality-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
Aparece en las colecciones: INTA

Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro sencillo del ítem