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dc.provenanceINTA-
dc.contributorDemars, Julie-
dc.contributorCano Pereira, Ema Margarita-
dc.contributorDroulhet, Laurence-
dc.contributorPlisson-Petit, Florence-
dc.contributorBardou, Philippe-
dc.contributorFabre, Stéphane-
dc.contributorServin, Bertrand-
dc.contributorSarry, Julien-
dc.contributorWoloszyn, Florent-
dc.contributorMulsant, Philippe-
dc.contributorFoulquier, Didier-
dc.contributorCarriere, Fabien-
dc.contributorAletru, Mathias-
dc.contributorRodde, Nathalie-
dc.contributorCauet, Stéphane-
dc.contributorBouchez, Olivier-
dc.contributorPirson, Maarten-
dc.contributorTosser-Klopp, Gwenola-
dc.contributorAllain, Daniel-
dc.creatorDemars, Julie-
dc.creatorCano Pereira, Ema Margarita-
dc.creatorDroulhet, Laurence-
dc.creatorPlisson-Petit, Florence-
dc.creatorBardou, Philippe-
dc.creatorFabre, Stéphane-
dc.creatorServin, Bertrand-
dc.creatorSarry, Julien-
dc.creatorWoloszyn, Florent-
dc.creatorMulsant, Philippe-
dc.creatorFoulquier, Didier-
dc.creatorCarriere, Fabien-
dc.creatorAletru, Mathias-
dc.creatorRodde, Nathalie-
dc.creatorCauet, Stéphane-
dc.creatorBouchez, Olivier-
dc.creatorPirson, Maarten-
dc.creatorTosser-Klopp, Gwenola-
dc.creatorAllain, Daniel-
dc.date2017-10-12T12:16:17Z-
dc.date2017-10-12T12:16:17Z-
dc.date2017-04-
dc.date.accessioned2019-04-29T16:27:42Z-
dc.date.available2019-04-29T16:27:42Z-
dc.date.issued2017-10-12T12:16:17Z-
dc.date.issued2017-10-12T12:16:17Z-
dc.date.issued2017-04-
dc.identifier0737-4038 (Print)-
dc.identifier1537-1719 (Online)-
dc.identifierhttps://doi.org/10.1093/molbev/msx114-
dc.identifierhttp://hdl.handle.net/20.500.12123/1471-
dc.identifierhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455980/-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/313702-
dc.descriptionThe composition and structure of fleece variation observed in mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece. Here, we report that the “woolly” allele results from the insertion of an antisense EIF2S2 retrogene (called asEIF2S2) into the 30 UTR of the IRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation.-
dc.descriptionInst. de Genética "Ewald A. Favret"- IGEAF-
dc.descriptionFil: Demars, Julie. Université de Toulouse. GenPhySE; Francia-
dc.descriptionFil: Cano Pereira, Ema Margarita. INTA. Instituto de Genética "Ewald A. Favret"; Argentina-
dc.descriptionFil: Droulhet, Laurence. Université de Toulouse. GenPhySE; Francia-
dc.descriptionFil: Plisson-Petit, Florence. Université de Toulouse. GenPhySE; Francia-
dc.descriptionFil: Bardou, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique. Systèmes d'information des Génomes des Animaux d'élevage; Francia-
dc.descriptionFil: Fabre, Stéphane. Université de Toulouse. GenPhySE; Francia-
dc.descriptionFil: Servin, Bertrand. Université de Toulouse. GenPhySE; Francia-
dc.descriptionFil: Sarry, Julien. Université de Toulouse. GenPhySE; Francia-
dc.descriptionFil: Woloszyn, Florent. Universitè de Toulouse. GenPhySE; Francia-
dc.descriptionFil: Mulsant, Philippe. Université de Toulouse. GenPhySE; Francia-
dc.descriptionFil: Foulquier, Didier. Institut National de la Recherche Agronomique. Domaine Expérimental de La Fage; Francia-
dc.descriptionFil: Carriere, Fabien. Institut National de la Recherche Agronomique. Domaine Expérimental de La Fage; Francia-
dc.descriptionFil: Aletru, Mathias. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique. Domaine Expérimental de La Fage; Francia-
dc.descriptionFil: Rodde, Nathalie. Institut National de la Recherche Agronomique. Centre National de Ressources Génomiques Végétales; Francia-
dc.descriptionFil: Cauet, Stéphane. Institut National de la Recherche Agronomique. Centre National de Ressources Génomiques Végétales; Francia-
dc.descriptionFil: Tosser-Klopp, Gwenola. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique. Plateforme Génome et Transcriptome; Francia-
dc.descriptionFil: Allain, Daniel. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique. Plateforme Génome et Transcriptome; Francia-
dc.formatapplication/pdf-
dc.languageeng-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.sourceMolecular biology and evolution 34 (7) : 1722–1729. (July 2017)-
dc.sourcereponame:INTA Digital (INTA)-
dc.sourceinstname:Instituto Nacional de Tecnología Agropecuaria-
dc.sourceinstacron:INTA-
dc.source.uri0737-4038 (Print)-
dc.source.uri1537-1719 (Online)-
dc.source.urihttps://doi.org/10.1093/molbev/msx114-
dc.source.urihttp://hdl.handle.net/20.500.12123/1471-
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455980/-
dc.source.urihttps://doi.org/10.1093/molbev/msx114-
dc.source.urihttp://hdl.handle.net/20.500.12123/1471-
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455980/-
dc.subjectGenética-
dc.subjectOvinos-
dc.subjectGenomas-
dc.subjectMutación-
dc.subjectLana-
dc.subjectGenetics-
dc.subjectSheep-
dc.subjectGenomes-
dc.subjectMutation-
dc.subjectWool-
dc.titleGenome-wide identification of the mutation underlying fleece variation and discriminating ancestral hairy species from modern woolly sheep-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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