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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Universidad de Buenos Aires. Facultad de Ciencias Económicas | - |
| dc.creator | Mercer, Natalia | - |
| dc.creator | Ahmed, Hafiz | - |
| dc.creator | Etcheverry, Susana B. | - |
| dc.creator | Vasta, Gerardo R. | - |
| dc.creator | Cortizo, Ana María | - |
| dc.date | 2007 | - |
| dc.date.accessioned | 2019-06-19T20:37:24Z | - |
| dc.date.available | 2019-06-19T20:37:24Z | - |
| dc.date.issued | 2007 | - |
| dc.identifier | http://digital.cic.gba.gob.ar/handle/11746/4960 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar/jspui/handle/bnmm/327450 | - |
| dc.description | Advanced glycation end products (AGEs) have been proposed as the pathological mechanisms underlying diabetic chronic complications. They may also play a role in the pathogenesis of diabetic osteopenia, although their mechanisms of action remain unclear. We investigated the protein (immunofluorescence) and gene expression (realtime RT-PCR) of two receptors for AGEs, RAGE and galectin-3, as well as their regulation by AGEs, and the apoptotic effect on osteoblast-like cells (UMR106 and MC3T3E1) in culture. AGEs up-regulated the expression of RAGE and galectin-3 in both cells lines. These effects were accompanied by an increase in the corresponding mRNA in the non-tumoral MC3T3E1 but not in the osteosarcoma UMR106 cells. Finally, we demonstrated that a 24 h exposure to AGEs induced apoptosis in both cell lines. Thus, AGEs-receptors may play important roles in the bone alterations described in aging and diabetic patients. | - |
| dc.format | application/pdf | - |
| dc.format | 8 p. | - |
| dc.language | eng | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | Attribution 4.0 International (BY 4.0) | - |
| dc.source | reponame:CIC Digital (CICBA) | - |
| dc.source | instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires | - |
| dc.source | instacron:CICBA | - |
| dc.source.uri | http://digital.cic.gba.gob.ar/handle/11746/4960 | - |
| dc.subject | Ciencias Químicas | - |
| dc.title | Regulation of advanced glycation end product (AGE) receptors and apoptosis by AGEs in osteoblast-like cells | - |
| dc.type | info:eu-repo/semantics/conferenceObject | - |
| dc.type | info:eu-repo/semantics/submittedVersion | - |
| dc.type | info:ar-repo/semantics/documentoDeConferencia | - |
| Aparece en las colecciones: | Facultad de Ciencias Económicas. UBA | |
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