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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Universidad Nacional de Rosario.RepHipUNR | - |
| dc.creator | Rozados, Viviana R. | - |
| dc.creator | Sánchez, Andrea M. | - |
| dc.creator | Gervasoni, Silvia I. | - |
| dc.creator | Berra, Héctor H. | - |
| dc.creator | Matar, Pablo | - |
| dc.creator | Scharovsky, O. Graciela | - |
| dc.date | 2004-10 | - |
| dc.date | 2004-10 | - |
| dc.date.accessioned | 2019-07-15T18:40:52Z | - |
| dc.date.available | 2019-07-15T18:40:52Z | - |
| dc.date.issued | 2004-10 | - |
| dc.date.issued | 2004-10 | - |
| dc.identifier | Rozados, V. R., Sánchez, A. M., Gervasoni, S. I., Berra, H. H., Matar, P., & Graciela, S. O. (2004). Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity. Annals of Oncology, 15, 10, 1543-1550. | - |
| dc.identifier | 0923-7534 | - |
| dc.identifier | http://hdl.handle.net/2133/2013 | - |
| dc.identifier | http://hdl.handle.net/2133/2013 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar/jspui/handle/bnmm/567935 | - |
| dc.description | BACKGROUND: Our aim was to investigate the clinical efficacy and toxicity of metronomic administration of low-dose cyclophosphamide (Cy) in lymphoma and sarcoma rat tumour models. METHODS: Adult inbred rats were challenged with lymphoma TACB and sarcoma E100 s.c. on day 0. Animals were divided into two groups: group I, control, injected with saline three times a week; and group II, treated with Cy 10 mg/kg three times a week, from day 10 until the tumour was non-palpable, or 5 mg/kg three times a week from day 7. Tumours were measured and animals were weighed twice weekly. Periodic blood samples were taken for determination of urea, creatinine, serum glutamic-oxaloacetic transaminase, lactate dehydrogenase and haematological parameters. RESULTS: The administration of low-dose Cy eradicated established rat lymphomas and sarcomas; there was neither metastatic growth nor recurrence at primary sites for 100% of the lymphomas and 83% of the sarcomas. In addition, the treatment did not cause weight loss, and was devoid of haematological, cardiac, hepatic and renal toxicity. CONCLUSIONS: Metronomic administration of Cy at low doses on a thrice weekly schedule to already grown rat lymphomas and sarcomas demonstrated itself to be a successful antitumour therapy that did not cause weight loss and was devoid of haematological, cardiac, hepatic and renal toxicity. | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Oxford University Press | - |
| dc.relation | http://dx.doi.org/10.1093/annonc/mdh384 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.source | reponame:RepHipUNR (UNR) | - |
| dc.source | instname:Universidad Nacional de Rosario | - |
| dc.source | instacron:UNR | - |
| dc.source.uri | http://hdl.handle.net/2133/2013 | - |
| dc.subject | Cyclophosphamide | - |
| dc.subject | Lymphoma | - |
| dc.subject | Metronomic dosing | - |
| dc.subject | Sarcoma | - |
| dc.subject | Toxicity | - |
| dc.title | Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | artículo | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | Universidad Nacional de Rosario. RepHipUNR | |
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