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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Universidad Nacional de Rosario.RepHipUNR | - |
| dc.contributor | Dr. Mauricio Rassetto: asistencia técnica | - |
| dc.creator | Capiglioni, Alejo M. | - |
| dc.creator | Lorenzetti, Florencia | - |
| dc.creator | Quiroga, Ariel Darío | - |
| dc.creator | Parody, Juan Pablo | - |
| dc.creator | Ronco, María Teresa | - |
| dc.creator | Pisani, Gerardo Bruno | - |
| dc.creator | Carrillo, María Cristina | - |
| dc.creator | Ceballos, María Paula | - |
| dc.creator | Alvarez, María de Luján | - |
| dc.date | 2017-03-02 | - |
| dc.date | 2017-03-02 | - |
| dc.date.accessioned | 2019-07-15T19:05:13Z | - |
| dc.date.available | 2019-07-15T19:05:13Z | - |
| dc.date.issued | 2017-03-02 | - |
| dc.date.issued | 2017-03-02 | - |
| dc.identifier | 1436-6207 | - |
| dc.identifier | http://hdl.handle.net/2133/13719 | - |
| dc.identifier | http://hdl.handle.net/2133/13719 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar/jspui/handle/bnmm/570855 | - |
| dc.description | PURPOSE:Glycerol usage is increasing in food industry for human and animal nutrition. This study analyzed the impact of glycerol metabolism when orally supplemented during the early stage of rat liver carcinogenesis.METHODS:Wistar rats were subjected to a 2-phase model of hepatocarcinogenesis (initiated-promoted, IP group). IP animals also received glycerol by gavage (200 mg/kg body weight, IPGly group).RESULTS:Glycerol treatment reduced the volume of preneoplastic lesions by decreasing the proliferative status of liver foci, increasing the expression of p53 and p21 proteins and reducing the expression of cyclin D1 and cyclin-dependent kinase 1. Besides, apoptosis was enhanced in IPGly animals, given by an increment of Bax/Bcl-2 ratio, Bad and PUMA mitochondrial expression, a concomitant increase in cytochrome c release and caspase-3 activation. Furthermore, hepatic levels of glycerol phosphate and markers of oxidative stress were increased in IPGly rats. Oxidative stress intermediates act as intracellular messengers, inducing p53 activation and changes in JNK and Erk signaling pathways, with JNK activation and Erk inhibition.CONCLUSION:The present work provides novel data concerning the preventive actions of glycerol during the development of liver cancer and represents an economically feasible intervention to treat high-risk individuals. | - |
| dc.description | Fil: Capiglioni, Alejo M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Lorenzetti, Florencia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Quiroga, Ariel Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Quiroga, Ariel Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Morfología; Argentina. | - |
| dc.description | Fil: Parody, Juan Pablo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Ronco, María Teresa. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Pisani, Gerardo Bruno. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Morfología; Argentina. | - |
| dc.description | Fil: Carrillo, María Cristina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Carrillo, María Cristina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Morfología; Argentina. | - |
| dc.description | Fil: Ceballos, María Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Alvarez, María de Luján. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Alvarez, María de Luján. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Morfología; Argentina. | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Springer | - |
| dc.relation | https://link.springer.com/article/10.1007%2Fs00394-017-1404-4#aboutcontent | - |
| dc.relation | http://dx.doi.org/10.1007/s00394-017-1404-4 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.source | reponame:RepHipUNR (UNR) | - |
| dc.source | instname:Universidad Nacional de Rosario | - |
| dc.source | instacron:UNR | - |
| dc.source.uri | http://hdl.handle.net/2133/13719 | - |
| dc.subject | Apoptosis | - |
| dc.subject | Glycerol | - |
| dc.subject | Liver Preneoplasia | - |
| dc.subject | Oxidative Stress | - |
| dc.title | Attenuation of liver cancer development by oral glycerol supplementation in the rat | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | artículo | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | Universidad Nacional de Rosario. RepHipUNR | |
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