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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Universidad Nacional de Rosario.RepHipUNR | - |
| dc.creator | Casella, María Laura | - |
| dc.creator | Parody, Juan Pablo | - |
| dc.creator | Ceballos, María Paula | - |
| dc.creator | Quiroga, Ariel Darío | - |
| dc.creator | Ronco, María Teresa | - |
| dc.creator | Francés, Daniel Eleazar | - |
| dc.creator | Monti, Juan Alberto | - |
| dc.creator | Pisani, Gerardo Bruno | - |
| dc.creator | Carnovale, Cristina Ester | - |
| dc.creator | Carrillo, María Cristina | - |
| dc.creator | Álvarez, María de Luján | - |
| dc.date | 2014-02-03 | - |
| dc.date | 2014-02-03 | - |
| dc.date.accessioned | 2019-07-15T19:05:14Z | - |
| dc.date.available | 2019-07-15T19:05:14Z | - |
| dc.date.issued | 2014-02-03 | - |
| dc.date.issued | 2014-02-03 | - |
| dc.identifier | 1613-4125 | - |
| dc.identifier | http://hdl.handle.net/2133/10486 | - |
| dc.identifier | http://hdl.handle.net/2133/10486 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar/jspui/handle/bnmm/570856 | - |
| dc.description | Quercetin is the most abundant flavonoid in human diet. It has special interest since it holds anticancerous properties. This study aims to clarify the mechanisms involved in quercetin effects during the occurrence of preneoplastic lesions in rat liver. Adult male Wistar rats were subjected to a two-phase model of hepatocarcinogenesis (IP group). IP animals also received quercetin 10 and 20 mg/kg body weight (IPQ10 and IPQ20 groups, respectively). Antioxidant defenses were modified by quercetin administration at both doses. However, only IPQ20 group showed a reduction in number and volume of preneoplastic lesions. This group showed increased apoptosis and a reduction in the proliferative index. In addition, IPQ20 group displayed a reduction of cell percentages in G1 and S phases, accumulation in G2 and decrease in M phase, with reduced expression of cyclin D1, cyclin A, cyclin B and cdk1. Interestingly, peroxisome proliferator-activated receptor α (PPARα) levels were reduced in IPQ20 group. The outcomes of this study represent a significant contribution to the current understanding on the preventive mechanisms of quercetin during the early stages of liver cancer development, demonstrating that in addition to its known proapoptotic characteristics, the flavonoid modulates the expression of critical cell cycle regulators and PPARα activity. | - |
| dc.description | Fil: Casella, María Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Parody, Juan Pablo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Ceballos, María Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Quiroga, Ariel Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Quiroga, Ariel Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Morfología; Argentina. | - |
| dc.description | Fil: Ronco, María Teresa. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Francés, Daniel Eleazar. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Monti, Juan Alberto. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Pisani, Gerardo Bruno. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Morfología; Argentina. | - |
| dc.description | Fil: Carnovale, Cristina Ester. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Carrillo, María Cristina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Carrillo, María Cristina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Morfología; Argentina. | - |
| dc.description | Fil: Álvarez, María de Luján. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina. | - |
| dc.description | Fil: Álvarez, María de Luján. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Morfología; Argentina. | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley | - |
| dc.relation | http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201300362/abstract?systemMessage=Please+be+advised+that+we+experienced+an+unexpected+issue+that+occurred+on+Saturday+and+Sunday+January+20th+and+21st+that+caused+the+site+to+be+down+for+an+extended+period+of+time+and+affected+the+ability+of+users+to+access+content+on+Wiley+Online+Library.+This+issue+has+now+been+fully+resolved.++We+apologize+for+any+inconvenience+this+may+have+caused+and+are+working+to+ensure+that+we+can+alert+you+immediately+of+any+unplanned+periods+of+downtime+or+disruption+in+the+future. | - |
| dc.relation | http://dx.doi.org/10.1002/mnfr.201300362 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.source | reponame:RepHipUNR (UNR) | - |
| dc.source | instname:Universidad Nacional de Rosario | - |
| dc.source | instacron:UNR | - |
| dc.source.uri | http://hdl.handle.net/2133/10486 | - |
| dc.subject | Liver Preneoplasia | - |
| dc.subject | Quercetin | - |
| dc.subject | Cell Cycle | - |
| dc.subject | Apoptosis | - |
| dc.title | Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | artículo | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | Universidad Nacional de Rosario. RepHipUNR | |
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