Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Universidad Nacional de Rosario.RepHipUNR | - |
| dc.creator | Cuesta, Santiago | - |
| dc.creator | Batuecas, Jorgelina | - |
| dc.creator | Severin, Maria Julia | - |
| dc.creator | Funes, Alejandrina | - |
| dc.creator | Rosso, Silvana | - |
| dc.creator | Pacchioni, Alejandra Maria | - |
| dc.date | 2016-12-07 | - |
| dc.date | 2016-12-07 | - |
| dc.date.accessioned | 2019-07-15T19:05:21Z | - |
| dc.date.available | 2019-07-15T19:05:21Z | - |
| dc.date.issued | 2016-12-07 | - |
| dc.date.issued | 2016-12-07 | - |
| dc.identifier | 1471-4159 | - |
| dc.identifier | http://hdl.handle.net/2133/10561 | - |
| dc.identifier | http://hdl.handle.net/2133/10561 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar/jspui/handle/bnmm/570865 | - |
| dc.description | Cocaine addiction is a chronic relapsing disorder characterized by the loss of control over drug-seeking and taking, and continued drug use regardless of adverse consequences. Despite years of research, effective treatments for psycho-stimulant addiction have not been identified. Persistent vulnerability to relapse arises from a number of long-lasting adaptations in the reward circuitry that mediate the enduring response to the drug. Recently, we reported that the activity of the canonical or Wnt/β-catenin pathway in the prefrontal cortex (PFC) is very important in the early stages of cocaine-induced neuroadaptations. In the present work, our main goal was to elucidate the relevance of this pathway in cocaine-induced long-term neuroadaptations that may underlie relapse. We found that a cocaine challenge, after a period of abstinence, induced an increase in the activity of the pathway which is revealed as an increase in the total and nuclear levels of β-catenin (final effector of the pathway) in the nucleus accumbens (NAcc), together with a decrease in the activity of glycogen synthase kinase 3β (GSK3β). Moreover, we found that the pharmacological modulation of the activity of the pathway has long-term effects on the cocaine-induced neuroplasticity at behavioral and molecular levels. All the results imply that changes in the Wnt/β-catenin pathway effectors are long-term neuroadaptations necessary for the behavioral response to cocaine. Even though more research is needed, the present results introduce the Wnt canonical pathway as a possible target to manage cocaine long-term neuroadaptations. | - |
| dc.description | Fil: Cuesta, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina. | - |
| dc.description | Fil: Cuesta, Santiago. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias de los Alimentos y del Medioambiente. Área Toxicología; Argentina. | - |
| dc.description | Fil: Batuecas, Jorgelina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias de los Alimentos y del Medioambiente. Área Toxicología; Argentina. | - |
| dc.description | Fil: Severin, María Julia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias de los Alimentos y del Medioambiente. Área Toxicología; Argentina. | - |
| dc.description | Fil: Funes, Alejandrina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina. | - |
| dc.description | Fil: Funes, Alejandrina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias de los Alimentos y del Medioambiente. Área Toxicología; Argentina. | - |
| dc.description | Fil: Rosso, Silvana B. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina. | - |
| dc.description | Fil: Rosso, Silvana B. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias de los Alimentos y del Medioambiente. Área Toxicología; Argentina. | - |
| dc.description | Fil: Pacchioni, Alejandra María. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina. | - |
| dc.description | Fil: Pacchioni, Alejandra María. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias de los Alimentos y del Medioambiente. Área Toxicología; Argentina. | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley | - |
| dc.relation | http://dx.doi.org/doi:10.1111/jnc.13863 | - |
| dc.relation | http://onlinelibrary.wiley.com/doi/10.1111/jnc.13863/abstract | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.source | reponame:RepHipUNR (UNR) | - |
| dc.source | instname:Universidad Nacional de Rosario | - |
| dc.source | instacron:UNR | - |
| dc.source.uri | http://hdl.handle.net/2133/10561 | - |
| dc.subject | Nucleus Accumbens | - |
| dc.subject | Cocaine | - |
| dc.subject | Lithium Chloride | - |
| dc.subject | Long-term Neuroadaptations | - |
| dc.subject | Sensitization | - |
| dc.title | Role of Wnt/beta-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity : a possible novel target for addiction treatment | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | artículo | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | Universidad Nacional de Rosario. RepHipUNR | |
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