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  2. FCEN
  3. FCEN - Facultad de Ciencias Exactas y Naturales. UBA
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dc.provenanceFacultad de Ciencias Exactas y Naturales de la UBA-
dc.contributor<div class="autor_fcen" id="3432">Galli, S.</div>-
dc.contributorJahn, O.-
dc.contributorHitt, R.-
dc.contributorHesse, D.-
dc.contributorOpitz, L.-
dc.contributorPlessmann, U.-
dc.contributorUrlaub, H.-
dc.contributorPoderoso, J.J.-
dc.contributor<div class="autor_fcen" id="4466">Jares-Erijman, E.A.</div>-
dc.contributorJovin, T.M.-
dc.creator<div class="autor_fcen" id="3432">Galli, S.</div>-
dc.creatorJahn, O.-
dc.creatorHitt, R.-
dc.creatorHesse, D.-
dc.creatorOpitz, L.-
dc.creatorPlessmann, U.-
dc.creatorUrlaub, H.-
dc.creatorPoderoso, J.J.-
dc.creator<div class="autor_fcen" id="4466">Jares-Erijman, E.A.</div>-
dc.creatorJovin, T.M.-
dc.date.accessioned2018-05-04T22:07:06Z-
dc.date.accessioned2018-05-28T15:48:58Z-
dc.date.available2018-05-04T22:07:06Z-
dc.date.available2018-05-28T15:48:58Z-
dc.date.issued2009-
dc.identifier.urihttp://10.0.0.11:8080/jspui/handle/bnmm/68590-
dc.descriptionExtracellular signal-regulated protein kinase 1 and 2 (ERK1/2) are members of the MAPK family and participate in the transduction of stimuli in cellular responses. Their long-term actions are accomplished by promoting the expression of specific genes whereas faster responses are achieved by direct phosphorylation of downstream effectors located throughout the cell. In this study we determined that hERK1 translocates to the mitochondria of HeLa cells upon a proliferative stimulus. In the mitochondrial environment, hERK1 physically associates with (i) at least 5 mitochondrial proteins with functions related to transport (i.e. VDAC1), signalling, and metabolism; (ii) histones H2A and H4; and (iii) other cytosolic proteins. This work indicates for the first time the presence of diverse ERK-complexes in mitochondria and thus provides a new perspective for assessing the functions of ERK1 in the regulation of cellular signalling and trafficking in HeLa cells. © 2009 Galli et al.-
dc.descriptionFil:Galli, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.-
dc.descriptionFil:Jares-Erijman, E.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.-
dc.formatapplication/pdf-
dc.languageeng-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by/2.5/ar-
dc.sourcePLoS ONE 2009;4(10)-
dc.source.urihttp://digital.bl.fcen.uba.ar/Download/paper/paper_19326203_v4_n10_p_Galli.pdf-
dc.subjecthistone H2A-
dc.subjecthistone H4-
dc.subjectmitogen activated protein kinase 1-
dc.subjectmitogen activated protein kinase 3-
dc.subjectvoltage dependent anion channel-
dc.subjectglutathione transferase-
dc.subjectarticle-
dc.subjectcomplex formation-
dc.subjectcontrolled study-
dc.subjectenzyme activity-
dc.subjectgene control-
dc.subjectgene expression-
dc.subjectgene location-
dc.subjectHeLa cell-
dc.subjecthuman-
dc.subjecthuman cell-
dc.subjectmitochondrion-
dc.subjectnucleotide sequence-
dc.subjectprotein protein interaction-
dc.subjectprotein transport-
dc.subjectsignal transduction-
dc.subjectamino acid sequence-
dc.subjectcell proliferation-
dc.subjectgene expression profiling-
dc.subjectgene expression regulation-
dc.subjectmass spectrometry-
dc.subjectmetabolism-
dc.subjectmethodology-
dc.subjectmolecular genetics-
dc.subjectproteomics-
dc.subjectsequence homology-
dc.subjectAmino Acid Sequence-
dc.subjectCell Proliferation-
dc.subjectGene Expression Profiling-
dc.subjectGene Expression Regulation, Enzymologic-
dc.subjectGene Expression Regulation, Neoplastic-
dc.subjectGlutathione Transferase-
dc.subjectHela Cells-
dc.subjectHumans-
dc.subjectMAP Kinase Signaling System-
dc.subjectMitochondria-
dc.subjectMitogen-Activated Protein Kinase 3-
dc.subjectMolecular Sequence Data-
dc.subjectProteomics-
dc.subjectSequence Homology, Amino Acid-
dc.subjectSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization-
dc.titleA new paradigm for MAPK: Structural interactions of hERK1 with mitochondria in HeLa cells-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:ar-repo/semantics/artículo-
dc.typeinfo:eu-repo/semantics/publishedVersion-
Aparece en las colecciones: FCEN - Facultad de Ciencias Exactas y Naturales. UBA

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