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dc.provenanceFacultad de Ciencias Exactas y Naturales de la UBA-
dc.contributorGómez Ravetti, M.-
dc.contributorRosso, O.A.-
dc.contributorBerretta, R.-
dc.contributorMoscato, P.-
dc.creatorGómez Ravetti, M.-
dc.creatorRosso, O.A.-
dc.creatorBerretta, R.-
dc.creatorMoscato, P.-
dc.date.accessioned2018-05-04T21:55:26Z-
dc.date.accessioned2018-05-28T15:49:02Z-
dc.date.available2018-05-04T21:55:26Z-
dc.date.available2018-05-28T15:49:02Z-
dc.date.issued2010-
dc.identifier.urihttp://10.0.0.11:8080/jspui/handle/bnmm/68598-
dc.descriptionBackground: Alzheimer's disease (AD) is characterized by a neurodegenerative progression that alters cognition. On a phenotypical level, cognition is evaluated by means of the MiniMental State Examination (MMSE) and the post-morten examination of Neurofibrillary Tangle count (NFT) helps to confirm an AD diagnostic. The MMSE evaluates different aspects of cognition including orientation, short-term memory (retention and recall), attention and language. As there is a normal cognitive decline with aging, and death is the final state on which NFT can be counted, the identification of brain gene expression biomarkers from these phenotypical measures has been elusive. Methodology/Principal Findings: We have reanalysed a microarray dataset contributed in 2004 by Blalock et al. of 31 samples corresponding to hippocampus gene expression from 22 AD subjects of varying degree of severity and 9 controls. Instead of only relying on correlations of gene expression with the associated MMSE and NFT measures, and by using modern bioinformatics methods based on information theory and combinatorial optimization, we uncovered a 1,372-probe gene expression signature that presents a high-consensus with established markers of progression in AD. The signature reveals alterations in calcium, insulin, phosphatidylinositol and wnt-signalling. Among the most correlated gene probes with AD severity we found those linked to synaptic function, neurofilament bundle assembly and neuronal plasticity. Conclusions/Significance: A transcription factors analysis of 1,372-probe signature reveals significant associations with the EGR/KROX family of proteins, MAZ, and E2F1. The gene homologous of EGR1, zif268, Egr-1 or Zenk, together with other members of the EGR family, are consolidating a key role in the neuronal plasticity in the brain. These results indicate a degree of commonality between putative genes involved in AD and prion-induced neurodegenerative processes that warrants further investigation. © 2010 Go ́mez Ravetti et al.-
dc.formatapplication/pdf-
dc.languageeng-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by/2.5/ar-
dc.sourcePLoS ONE 2010;5(4)-
dc.source.urihttp://digital.bl.fcen.uba.ar/Download/paper/paper_19326203_v5_n4_p_GomezRavetti.pdf-
dc.subjectbiological marker-
dc.subjectcalcium-
dc.subjectearly growth response factor-
dc.subjectepidermal growth factor receptor-
dc.subjectinsulin-
dc.subjectMyc associated zinc finger protein-
dc.subjectphosphatidylinositol-
dc.subjecttranscription factor-
dc.subjecttranscription factor E2F1-
dc.subjectunclassified drug-
dc.subjectWnt protein-
dc.subjectzinc finger protein-
dc.subjectAlzheimer disease-
dc.subjectarticle-
dc.subjectbioinformatics-
dc.subjectcalcium signaling-
dc.subjectclinical article-
dc.subjectcognitive defect-
dc.subjectcontrolled study-
dc.subjectdisease course-
dc.subjectdisease severity-
dc.subjectgene expression profiling-
dc.subjectgene expression regulation-
dc.subjectgene probe-
dc.subjecthippocampus-
dc.subjecthuman-
dc.subjecthuman tissue-
dc.subjectinformation science-
dc.subjectmicroarray analysis-
dc.subjectmini mental state examination-
dc.subjectnerve cell plasticity-
dc.subjectneurofibrillary tangle-
dc.subjectneurofilament-
dc.subjectsequence homology-
dc.subjectsignal transduction-
dc.subjectAlzheimer Disease-
dc.subjectBiological Markers-
dc.subjectCognition Disorders-
dc.subjectComputational Biology-
dc.subjectGene Expression Profiling-
dc.subjectHippocampus-
dc.subjectHumans-
dc.subjectNeuronal Plasticity-
dc.subjectOligonucleotide Array Sequence Analysis-
dc.subjectTranscription Factors-
dc.titleUncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:ar-repo/semantics/artículo-
dc.typeinfo:eu-repo/semantics/publishedVersion-
Aparece en las colecciones: FCEN - Facultad de Ciencias Exactas y Naturales. UBA

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