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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.provenance | Facultad de Ciencias Exactas y Naturales de la UBA | - |
dc.contributor | <div class="autor_fcen" id="1190">Bruno, L.</div> | - |
dc.contributor | <div class="autor_fcen" id="7706">Salierno, M.</div> | - |
dc.contributor | <div class="autor_fcen" id="9168">Wetzler, D.E.</div> | - |
dc.contributor | <div class="autor_fcen" id="2494">Despósito, M.A.</div> | - |
dc.contributor | <div class="autor_fcen" id="4951">Levi, V.</div> | - |
dc.creator | <div class="autor_fcen" id="1190">Bruno, L.</div> | - |
dc.creator | <div class="autor_fcen" id="7706">Salierno, M.</div> | - |
dc.creator | <div class="autor_fcen" id="9168">Wetzler, D.E.</div> | - |
dc.creator | <div class="autor_fcen" id="2494">Despósito, M.A.</div> | - |
dc.creator | <div class="autor_fcen" id="4951">Levi, V.</div> | - |
dc.date.accessioned | 2018-05-04T22:02:16Z | - |
dc.date.accessioned | 2018-05-28T15:49:04Z | - |
dc.date.available | 2018-05-04T22:02:16Z | - |
dc.date.available | 2018-05-28T15:49:04Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://10.0.0.11:8080/jspui/handle/bnmm/68602 | - |
dc.description | The organization of the cytoplasm is regulated by molecular motors which transport organelles and other cargoes along cytoskeleton tracks. Melanophores have pigment organelles or melanosomes that move along microtubules toward their minus and plus end by the action of cytoplasmic dynein and kinesin-2, respectively. In this work, we used single particle tracking to characterize the mechanical properties of motor-driven organelles during transport along microtubules. We tracked organelles with high temporal and spatial resolutions and characterized their dynamics perpendicular to the cytoskeleton track. The quantitative analysis of these data showed that the dynamics is due to a spring-like interaction between melanosomes and microtubules in a viscoelastic microenvironment. A model based on a generalized Langevin equation explained these observations and predicted that the stiffness measured for the motor complex acting as a linker between organelles and microtubules is ~ one order smaller than that determined for motor proteins in vitro. This result suggests that other biomolecules involved in the interaction between motors and organelles contribute to the mechanical properties of the motor complex. We hypothesise that the high flexibility observed for the motor linker may be required to improve the efficiency of the transport driven by multiple copies of motor molecules. © 2011 Bruno et al. | - |
dc.description | Fil:Bruno, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. | - |
dc.description | Fil:Salierno, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. | - |
dc.description | Fil:Wetzler, D.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. | - |
dc.description | Fil:Despósito, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. | - |
dc.description | Fil:Levi, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. | - |
dc.format | application/pdf | - |
dc.language | eng | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.rights | http://creativecommons.org/licenses/by/2.5/ar | - |
dc.source | PLoS ONE 2011;6(4) | - |
dc.source.uri | http://digital.bl.fcen.uba.ar/Download/paper/paper_19326203_v6_n4_p_Bruno.pdf | - |
dc.subject | dynactin | - |
dc.subject | dynein adenosine triphosphatase | - |
dc.subject | kinesin | - |
dc.subject | molecular motor | - |
dc.subject | microtubule associated protein | - |
dc.subject | animal cell | - |
dc.subject | article | - |
dc.subject | cell organelle | - |
dc.subject | cell tracking | - |
dc.subject | controlled study | - |
dc.subject | gene dosage | - |
dc.subject | in vitro study | - |
dc.subject | melanosome | - |
dc.subject | microtubule | - |
dc.subject | molecular dynamics | - |
dc.subject | nonhuman | - |
dc.subject | protein function | - |
dc.subject | protein interaction | - |
dc.subject | protein stiffness | - |
dc.subject | protein transport | - |
dc.subject | quantitative analysis | - |
dc.subject | viscoelasticity | - |
dc.subject | Xenopus laevis | - |
dc.subject | animal | - |
dc.subject | biological model | - |
dc.subject | biomechanics | - |
dc.subject | cell survival | - |
dc.subject | elasticity | - |
dc.subject | mechanics | - |
dc.subject | metabolism | - |
dc.subject | viscosity | - |
dc.subject | Animals | - |
dc.subject | Biomechanics | - |
dc.subject | Cell Survival | - |
dc.subject | Elasticity | - |
dc.subject | Mechanical Processes | - |
dc.subject | Melanosomes | - |
dc.subject | Microtubule-Associated Proteins | - |
dc.subject | Microtubules | - |
dc.subject | Models, Biological | - |
dc.subject | Molecular Motor Proteins | - |
dc.subject | Protein Transport | - |
dc.subject | Viscosity | - |
dc.subject | Xenopus laevis | - |
dc.title | Mechanical properties of organelles driven by microtubule-dependent molecular motors in living cells | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:ar-repo/semantics/artículo | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
Aparece en las colecciones: | FCEN - Facultad de Ciencias Exactas y Naturales. UBA |
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