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  3. FCEN - Facultad de Ciencias Exactas y Naturales. UBA
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dc.provenanceFacultad de Ciencias Exactas y Naturales de la UBA-
dc.contributorGonzález, I.T.-
dc.contributorBarrientos, G.-
dc.contributorFreitag, N.-
dc.contributorOtto, T.-
dc.contributorThijssen, V.L.J.L.-
dc.contributorMoschansky, P.-
dc.contributorvon Kwiatkowski, P.-
dc.contributorKlapp, B.F.-
dc.contributorWinterhager, E.-
dc.contributorBauersachs, S.-
dc.contributorBlois, S.M.-
dc.creatorGonzález, I.T.-
dc.creatorBarrientos, G.-
dc.creatorFreitag, N.-
dc.creatorOtto, T.-
dc.creatorThijssen, V.L.J.L.-
dc.creatorMoschansky, P.-
dc.creatorvon Kwiatkowski, P.-
dc.creatorKlapp, B.F.-
dc.creatorWinterhager, E.-
dc.creatorBauersachs, S.-
dc.creatorBlois, S.M.-
dc.date.accessioned2018-05-04T21:59:04Z-
dc.date.accessioned2018-05-28T15:49:08Z-
dc.date.available2018-05-04T21:59:04Z-
dc.date.available2018-05-28T15:49:08Z-
dc.date.issued2012-
dc.identifier.urihttp://10.0.0.11:8080/jspui/handle/bnmm/68611-
dc.descriptionDendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive. Using two different strategies to manipulate the frequency of NK cells and DC during gestation, we investigated their relative impact on the decidualization process and on angiogenic responses that characterize murine implantation. Manipulation of the frequency of NK cells, DC or both lead to a defective decidual response characterized by decreased proliferation and differentiation of stromal cells. Whereas no detrimental effects were evident upon expansion of DC, NK cell ablation in such expanded DC mice severely compromised decidual development and led to early pregnancy loss. Pregnancy failure in these mice was associated with an unbalanced production of anti-angiogenic signals and most notably, with increased expression of genes related to inflammation and immunogenic activation of DC. Thus, NK cells appear to play an important role counteracting potential anomalies raised by DC expansion and overactivity in the decidua, becoming critical for normal pregnancy progression. © 2012 González et al.-
dc.formatapplication/pdf-
dc.languageeng-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by/2.5/ar-
dc.sourcePLoS ONE 2012;7(10)-
dc.source.urihttp://digital.bl.fcen.uba.ar/Download/paper/paper_19326203_v7_n10_p_Gonzalez.pdf-
dc.subjectangiopoietin 1-
dc.subjectglycoprotein p 15095-
dc.subjectanimal cell-
dc.subjectanimal tissue-
dc.subjectarticle-
dc.subjectcell differentiation-
dc.subjectcell expansion-
dc.subjectcell interaction-
dc.subjectcell proliferation-
dc.subjectcell shape-
dc.subjectcontrolled study-
dc.subjectdecidualization-
dc.subjectdendritic cell-
dc.subjectfemale-
dc.subjectfirst trimester pregnancy-
dc.subjectflow cytometry-
dc.subjectfluorescence activated cell sorting-
dc.subjectgene expression-
dc.subjecthistopathology-
dc.subjectimmunogenicity-
dc.subjectimmunohistochemistry-
dc.subjectinflammation-
dc.subjectmouse-
dc.subjectnatural killer cell-
dc.subjectnidation-
dc.subjectnonhuman-
dc.subjectpregnancy-
dc.subjectpregnancy disorder-
dc.subjectquantitative analysis-
dc.subjectreverse transcription polymerase chain reaction-
dc.subjectstroma cell-
dc.subjectT cell depletion-
dc.subjectuterine cervix-
dc.subjectAnimals-
dc.subjectDendritic Cells-
dc.subjectEnzyme-Linked Immunosorbent Assay-
dc.subjectFemale-
dc.subjectImmunohistochemistry-
dc.subjectKiller Cells, Natural-
dc.subjectMale-
dc.subjectMice-
dc.subjectOligonucleotide Array Sequence Analysis-
dc.subjectPregnancy-
dc.subjectReverse Transcriptase Polymerase Chain Reaction-
dc.subjectUterus-
dc.titleUterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:ar-repo/semantics/artículo-
dc.typeinfo:eu-repo/semantics/publishedVersion-
Aparece en las colecciones: FCEN - Facultad de Ciencias Exactas y Naturales. UBA

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