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  3. FCEN - Facultad de Ciencias Exactas y Naturales. UBA
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dc.provenanceFacultad de Ciencias Exactas y Naturales de la UBA-
dc.contributorScolz, M.-
dc.contributorWidlund, P.O.-
dc.contributorPiazza, S.-
dc.contributorBublik, D.R.-
dc.contributorReber, S.-
dc.contributorPeche, L.Y.-
dc.contributorCiani, Y.-
dc.contributorHubner, N.-
dc.contributorIsokane, M.-
dc.contributor<div class="autor_fcen" id="5899">Monte, M.</div>-
dc.contributorEllenberg, J.-
dc.contributorHyman, A.A.-
dc.contributorSchneider, C.-
dc.contributorBird, A.W.-
dc.creatorScolz, M.-
dc.creatorWidlund, P.O.-
dc.creatorPiazza, S.-
dc.creatorBublik, D.R.-
dc.creatorReber, S.-
dc.creatorPeche, L.Y.-
dc.creatorCiani, Y.-
dc.creatorHubner, N.-
dc.creatorIsokane, M.-
dc.creator<div class="autor_fcen" id="5899">Monte, M.</div>-
dc.creatorEllenberg, J.-
dc.creatorHyman, A.A.-
dc.creatorSchneider, C.-
dc.creatorBird, A.W.-
dc.date.accessioned2018-05-04T22:04:43Z-
dc.date.accessioned2018-05-28T15:49:14Z-
dc.date.available2018-05-04T22:04:43Z-
dc.date.available2018-05-28T15:49:14Z-
dc.date.issued2012-
dc.identifier.urihttp://10.0.0.11:8080/jspui/handle/bnmm/68622-
dc.descriptionThe regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules and microtubule-associated proteins regulate multiple pathways promoting cell migration remains unclear. Microtubule plus-end binding proteins (+TIPs) are emerging as important players in many cellular functions, including cell migration. Here we identify a +TIP, GTSE1, that promotes cell migration. GTSE1 accumulates at growing microtubule plus ends through interaction with the EB1+TIP. The EB1-dependent +TIP activity of GTSE1 is required for cell migration, as well as for microtubule-dependent disassembly of focal adhesions. GTSE1 protein levels determine the migratory capacity of both nontransformed and breast cancer cell lines. In breast cancers, increased GTSE1 expression correlates with invasive potential, tumor stage, and time to distant metastasis, suggesting that misregulation of GTSE1 expression could be associated with increased invasive potential. © 2012 Scolz et al.-
dc.descriptionFil:Monte, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.-
dc.formatapplication/pdf-
dc.languageeng-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by/2.5/ar-
dc.sourcePLoS ONE 2012;7(12)-
dc.source.urihttp://digital.bl.fcen.uba.ar/Download/paper/paper_19326203_v7_n12_p_Scolz.pdf-
dc.subjectbinding protein-
dc.subjectend binding 1 protein-
dc.subjectG2 and S phase expressed 1 protein-
dc.subjectmicrotubule associated protein-
dc.subjectmicrotubule plus end tracking protein-
dc.subjectmicrotubule protein-
dc.subjectunclassified drug-
dc.subjectarticle-
dc.subjectbreast cancer-
dc.subjectcancer cell culture-
dc.subjectcell migration-
dc.subjectcontrolled study-
dc.subjectfocal adhesion-
dc.subjecthuman-
dc.subjecthuman cell-
dc.subjectmicrotubule-
dc.subjectnucleotide sequence-
dc.subjectprotein function-
dc.subjectprotein protein interaction-
dc.subjectregulatory mechanism-
dc.subjectBreast Neoplasms-
dc.subjectCell Line-
dc.subjectCell Movement-
dc.subjectDNA Primers-
dc.subjectFemale-
dc.subjectFluorescent Antibody Technique-
dc.subjectGene Expression Profiling-
dc.subjectGene Expression Regulation, Neoplastic-
dc.subjectHumans-
dc.subjectImmunoprecipitation-
dc.subjectKaplan-Meier Estimate-
dc.subjectMass Spectrometry-
dc.subjectMicroscopy, Fluorescence-
dc.subjectMicrotubule-Associated Proteins-
dc.subjectMicrotubules-
dc.subjectNeoplasm Invasiveness-
dc.subjectReal-Time Polymerase Chain Reaction-
dc.subjectRNA Interference-
dc.subjectRNA, Small Interfering-
dc.titleGTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:ar-repo/semantics/artículo-
dc.typeinfo:eu-repo/semantics/publishedVersion-
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